Objective: To explore the effect of constructing a full-time stratified group in the prevention and intervention of deep vein thrombosis after lower extremity fracture surgery. Methods: Using prospective clinical studies, A total of 106 patients admitted to Xishan People’s Hospital of Wuxi City from May 2020 to May 2021 were selected and randomly divided into an experience group and a control group, with 53 cases in each group. The incidence of deep vein thrombosis, coagulation index, negative emotion score, Activity of Daily Living Scale (ADL) score, Hospital for Special Surgery Knee Score (HSS) score, Harris score and complication rate were compared between the two groups. Results: The activated partial thromboplastin time (APTT), antithrombin (AT), prothrombin time (PT) and thrombin time (TT) levels of the experience group after intervention were higher than those of the control group, and the D-dimer (D-D) and plasma fibrinogen (Fbg) levels of the experience group were lower than those of the control group (P<0.05); The HAMA and HAMD scores of the experience group after intervention were lower than those of the control group (P<0.05); the ADL, HSS and Harris scores of the experience group were higher than those of the control group after intervention (P<0.05); the total postoperative complication rate of the experience group was lower than that of the control group (P<0.05). Conclusion: The establishment of a full-time stratified group in the prevention and intervention of prevention of deep vein thrombosis after lower extremity fractures can improve blood coagulation function and knee joint function, improve the ability of daily living, thereby alleviating negative emotions.