红细胞分布宽度与未经治疗的2型糖尿病患者肾功能关系
| 作者: |
1程艳,
1宋丹丹,
1樊一筠,
1孙长丽
1 郑州市第三人民医院肾内科，郑州 450000 |
| 通讯: |
孙长丽
Email: sunchangli86@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.02.018 |
摘要
目的：探讨红细胞分布宽度(red cell distribution width，RDW)与未经治疗的糖尿病患者肾功能关系。方法：收集河南省郑州市第三人民医院2015年8—10月335例未经治疗的原发性糖尿病病人，按照尿微量白蛋白量分为对照组(215例)和病例组(120例)，收集生理及实验室检查数据，比较两组各项指标的差异。结果：病例组的RDW要显著高于对照组，两组在吸烟、腰围、空腹血糖和尿酸水平差异均有统计学意义(P<0.05)。RDW预测血压形态的受试者工作特征曲线(receiver operating characteristic curve，ROC)下面积为0.74(95%CI 0.69~0.78)，灵敏度为78.1%，特异度为64.1%，多元logistic回归显示RDW的比值比为2.75(95%CI 1.45~4.33，P<0.001)。结论：在未经治疗的糖尿病人群中，RDW可能是预测糖尿病早期肾功能损害一个有价值的指标。
关键词：
糖尿病
红细胞分布宽度
尿微量白蛋白
Association between red blood cell distribution and renal function in patients with untreated type 2 diabetes mellitus
CorrespondingAuthor: SUN Zhangli Email: sunchangli86@126.com
DOI: 10.3978/j.issn.2095-6959.2017.02.018
Abstract
Objective: To explore the association between red cell distribution width (RDW) and renal function in patients with untreated type 2 diabetes mellitus (T2DM). Methods: A total of 335 T2DM patients without drug treatment were recruited from August to October 2015. Patients were divided into a control group (215 patients) and a case group (120 patients), the physiological and laboratory data were collected and compared. Results: Compared with the control group, the case group had higher RDW (P<0.001). The differences in smoking, waist index, fasting blood glucose level, and uric acid level were significant between two groups. The receiver operating characteristics curves (ROC) explored the relationship between microalbuminuria and RDW. The area under the curve were 0.74 (95%CI 0.69–0.78; P<0.001), with a sensitivity of 71.3% and specificity of 66.9%. The multiple logistic regression indicated that RDW (odds ratio=2.75, 95% CI: 1.45–4.33, P<0.001) was an independent risk factor of MAU in newly diagnosed T2DM. Conclusion: RDW may be treated as effective predictive index in the evaluation of diabetes nephropathy.