文章摘要

中性粒细胞/淋巴细胞、血小板/淋巴细胞对原发性痛风患者病情的评估价值

作者: 1陈玉雅, 2刘赞, 1邱剑梅, 1王小冰, 1张芬芬, 3陈清华, 1邢诒喜
1 海南医学院第二附属医院风湿免疫科，海口 570311
2 海南医学院第二附属医院热带病科，海口 570311
3 海南医学院第二附属医院内分泌科，海口 570311
通讯: 邢诒喜 Email: xyx13647545564@163.com
DOI: 10.3978/j.issn.2095-6959.2022.06.007

摘要

目的：探讨中性粒细胞淋巴细胞比值(neutrophil lymphocyte ratio，NLR)、血小板淋巴细胞比值(platelet lymphocyte ratio，PLR)对原发性痛风患者病情评估的检测价值。方法：选取2019年8月至2021年7月海南医学院第二附属医院风湿免疫科和内分泌科收治的102例原发性痛风患者，其中病情处于急性期和间歇期分别57例和45例，分别记为急性期组与间歇期组。比较两组人口学资料、NLR、PLR和其他实验室指标[血细胞沉降率(erythrocyte sedimentation rate，ESR)、C反应蛋白(C-reactive protein，CRP)、白细胞介素-1β(interleukin-1 β，IL-1β)、血尿酸(uric acid，UA)]；采用Spearman线性相关法分析NLR、PLR与实验室指标的相关性，绘制受试者工作特征(receiver operating characteristic，ROC)曲线评价NLR、PLR对痛风病情活动度的评估价值。结果：急性期组NLR、PLR、ESR、CRP、IL-1β、UA水平均高于间歇期组(均P<0.05)。痛风患者NLR、PLR与ESR、CRP、IL-1β、UA均呈正相关(rNLR=0.476、0.512、0.497、0.394，rPLR=0.491、0.479、0.503、0.387，均P<0.05)。NLR、PLR评估痛风疾病活动度的曲线下面积(area under curve，AUC)分别为0.751(95%CI：0.627~0.876)、0.743(95%CI：0.619~0.868)，灵敏度分别为77.19%、73.68%，特异度分别为64.44%、71.11%。结论：原发性痛风患者NLR、PLR与痛风病情活动程度密切相关，为临床病情评估提供参考依据。
关键词： 原发性痛风；急性期；间歇期；中性粒细胞/淋巴细胞比值；血小板/淋巴细胞；相关性；评估价值

Evaluation value of neutrophils/lymphocytes and platelets/lymphocytes in the evaluation of patients with primary gout

Authors: 1CHEN Yuya, 2LIU Zan, 1QIU Jianmei, 1WANG Xiaobing, 1ZHANG Fenfen, 3CHEN Qinghua, 1XING Yixi
1 Department of Rheumatology and Immunology, Second Affiliated Hospital of Hainan Medical University, Haikou 570311, China
2 Department of Tropical Diseases, Second Affiliated Hospital of Hainan Medical University, Haikou 570311, China
3 Department of Endocrinology, Second Affiliated Hospital of Hainan Medical University, Haikou 570311, China

CorrespondingAuthor: XING Yixi Email: xyx13647545564@163.com

DOI: 10.3978/j.issn.2095-6959.2022.06.007

Abstract

Objective: To explore the value of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in the evaluation of patients with primary gout. Methods: A total of 102 patients with primary gout admitted to the Department of Rheumatology and Immunology, and Department of Endocrinology of Second Affiliated Hospital of Hainan Medical University from August 2019 to July 2021 were selected. Among these patients, 57 cases were in the acute phase and 45 cases were in the intermittent phase, which were recorded as an acute phase group and an intermittent phase group respectively. The demographic data, NLR, PLR and other laboratory indexes [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-1β (IL-1β), blood uric acid (UA)] were compared between the two groups. Spearman linear correlation method was used to analyze the correlation between NLR, PLR and laboratory indexes. The evaluation value of NLR and PLR on gout disease activity was evaluated by receiver operating characteristic curve (ROC). Results: The levels of NLR, PLR, ESR, CRP, IL-1β and UA in the acute group were higher than those in intermittent group (all P<0.05). There was a positive correlation between NLR, PLR and ESR, CRP, IL-1β, UA in gout patients (rNLR=0.476, 0.512, 0.497, 0.394; rPLR=0.491, 0.479, 0.503, 0.387, all P<0.05). The area under the curve (AUC) of NLR PLR in evaluating gout activity were 0.751 (95%CI: 0.627–0.876) and 0.743 (95%CI: 0.619–0.868), respectively; and the sensitivity were 77.19% and 73.68%, and the specificity were 64.44% and 71.11%, respectively. Conclusion: NLR and PLR in patients with primary gout are closely related to the activity of gout, which provides a reference basis for clinical condition evaluation.

Keywords： primary gout; acute phase; intermittent period; neutrophil/lymphocyte ratio; platelets/lymphocytes; relevance; valuation value

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