Objective: To analyze the clinical effect of weight management in the prevention and treatment of chronic orthopedics diseases, and to establish a good diet and exercise habit for the patients with chronic orthopedics diseases. Methods: A total of 648 cases of chronic orthopedics diseases found by physical examination in our hospital from June 2012 to June 2015 were randomly divided into a control group and an observation group, 324 cases in each group. Patients in the control group were given the existing diet and exercise habits. Patients in the observation group were treated with strict weight management, including personalized diet and exercise guidance. All patients were managed for 12 months. The weight, joint pain scores and joint function before and after the intervention between the two groups were compared. Results: All indicators’ change of control group before intervention, 6 months after intervention, 12 months after the intervention was not significant (P>0.05). Obesity of the observation group before intervention, 6 months after intervention, 12 months after the intervention was significantly different (P<0.05), in which the overweight and obesity showed the most significant. The VAS score (7.40±1.68 vs. 6.94±1.42 vs. 6.16±1.49), BI index (68.84±4.73 vs. 74.82±5.33 vs. 79.52±5.41), and the excellent rate of joint function (56.48% vs. 65.74% vs. 75.00%) were significantly different between the two groups before intervention, 6 months and 12 months after intervention (P<0.05). Conclusion: Weight management can effectively improve the patients with obesity, reduce the symptoms of patients with chronic diseases, relieve pain, and improve the quality of life. It is worthy of attention.