Objective: To evaluate the fixation with a mini-locking plate via the mini-open sinus tarsi approach for intra-articular calcaneal fractures. Methods: Sixty-three patients with closed calcaneal fracture were treated with mini-locking plate via the mini-open sinus tarsi approach from October 2013 to December 2015. Patients were underwent a careful clinical and radiographic examination and evaluated with the Böhler angle, height and width of calcaneus before operation and at the last follow-up. The final curative effect was assessed according to the Maryland foot score. Results: All the patients were followed up for 10 to 24 months (mean, 18.7 months). The width of the calcaneus has restored to (37.04±5.83) mm at the last follow-up, while the width was (39.75±5.58) mm before the surgery. The heel bone height of the calcaneus has restored to (41.46±5.68) mm at the last follow-up, while the height is (38.75±5.38) mm before the surgery. The Böhler angle of the calcaneus has restored to 30.6°±4.64° at the last follow-up, while the height is 11.07°±13.39° before the surgery. There was significant difference of Böhler angle, height and width of calcaneus (P<0.05). According to Maryland foot score system, an excellent and good outcome of 87.3% was achieved, which the excellent, good and pass number of feet are 23, 32, 8. The complication formation rate is 9.5%. Conclusion: Sinus tarsi approach with a mini-locking plate technique is an effective method for the treatment of calcaneal fractures. It has the advantages of limit soft tissue complications, stable fixation, and early ambulation.