辛伐他汀致横纹肌溶解1例
| 作者: |
1罗举,
1张婷
1 长沙市中心医院老年科，长沙 410117 |
| 通讯: |
罗举
Email: 53185902@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.05.033 |
摘要
患者女，76岁，因“全身肌肉疼痛，伴乏力1周”入院。因冠心病长期服用降脂药“辛伐他汀(舒将之)20 mg/晚”，约2月前改用“辛伐他汀(京新)40 mg/晚”。入院后完善相关检查，肌酸激酶明显升高，肾功能轻度受损。诊断上考虑为：辛伐他汀导致的横纹肌溶解症。该病例特点：1)长期服用辛伐他汀未见不良反应，更换厂家及增加剂量2月后出现不良反应；2)肌酸激酶水平的显著升高；3)如此高的肌酶水平却并没有出现严重的肾功能损害，预后良好。
关键词：
辛伐他汀
横纹肌溶解
病例报告
A case report: a severe rhabdomyolysis associated with simvastatin
CorrespondingAuthor: LUO Ju Email: 53185902@qq.com
DOI: 10.3978/j.issn.2095-6959.2016.05.033
Abstract
A 76-year-old female was hospitalized because of “generalized muscle pain, with weakness for 1 week”. The patient had coronary heart disease and take simvastatin 20 mg per night. In recent 2 months, she changed the drug manufacturer and take 40 mg per night. The patient’s creatine kinase increased significantly with a slight renal impairment. The diagnosis is: rhabdomyolysis caused by simvastatin. The case has follow features: 1) before replaced the manufacturer and increased the dose, the adverse effects never appear; 2) a significantly increased creatine kinase level; 3) such a high level of creatine kinase did not cause serious renal failure.