Objective: To observe the effect of dural puncture epidural (DPE) technique compared with traditional epidural (EP) technique in maternal labor analgesia. Methods: A total of 178 primiparas with natural childbirth and labor analgesia in Changzhou Maternal and Child Health Care Hospital from October 2019 to September 2020 were included. They were randomly divided into EP group (n=89, epidural analgesia) and DPE group (n=89, dural puncture epidural analgesia), and both groups were given 0.1% ropivacaine + 0.5 μg/mL sufentanil analgesia. The Visual Analogue Scale (VAS) scores before, 30 min and 90 min after epidural analgesia were recorded; the labor analgesia, labor time, mode of delivery and adverse reactions of the two groups were recorded; the Apgar scores of the two groups were recorded; and the umbilical artery blood gas analysis of the two groups was compared. Results: The VAS score at 30 min and 90 min after administration in the DPE group were significantly lower than those in the EP group (P<0.05). Compared with the EP group, the number of PCA and the dosage of sufentanil and ropivacaine in the DPE group were significantly decreased (P<0.05), and the use rate of oxytocin was significantly decreased (P<0.05). There were no significant difference in labor time and delivery mode between the two groups (P>0.05). The incidence of adverse reactions in the DPE group was significantly lower than that in the EP group, and the difference was statistically significant (P<0.05). There were no significant difference in Apgar score and umbilical artery blood gas analysis between the two groups (P>0.05). Conclusion: Compared with EP technique, DPE technique can provide better analgesic effect in maternal labor analgesia, reduce dosage, reduce adverse reactions, and does not affect the labor process as well as maternal and infant outcomes.