Ghrelin对心血管系统的保护作用及其机制
| 作者: |
1王帆,
1吴梓璇,
1魏来,
1张晓卉
1 哈尔滨医科大学附属第一医院心内科，哈尔滨 150001 |
| 通讯: |
张晓卉
Email: maxiao19830522@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.07.034 |
| 基金: | 黑龙江省自然科学基金(LH2020H034)；黑龙江省博士后科研启动金(LBH-Q18080)；哈尔滨医科大学附属第一医院院杰出青年基金(HYD2020JQ0005)；哈尔滨医科大学附属第一医院院基金(2019M08)。 |
摘要
Protective effect of Ghrelin on cardiovascular system and its mechanism
CorrespondingAuthor: ZHANG Xiaohui Email: maxiao19830522@163.com
DOI: 10.3978/j.issn.2095-6959.2022.07.034
Foundation: This work was supported by the Natural Science Foundation of Heilongjiang Province (LH2020H034), the Heilongjiang Provincial Postdoctoral Research Start Fund (LBH-Q18080), the Excellent Youth Foundation of First Affiliated Hospital of Harbin Medical University (HYD2020JQ0005), and the Foundation of First Affiliated Hospital of Harbin Medical University (2019M08), China.
Abstract
Ghrelin, a polypeptide with 28 amino acid residues, is a specific ligand of growth hormone secretagogue receptor. Ghrelin is involved in controlling appetite and energy balance, regulating carbohydrate and lipid metabolism, cell proliferation and apoptosis, and regulating the function of gastrointestinal tract, bronchus, lung, and immune system. In recent years, it has been found that Ghrelin can protect cardiovascular system through anti-cardiomyocyte apoptosis, regulation of autophagy, anti-inflammation, anti-myocardial fibrosis, regulation of autonomic nervous system, and vascular protection.