Objective: To analyzed the effect of tamsulosin hydrochloride sustained-release capsules in the treatment of ureteral stones. Methods: Selected 312 patients with ureteral calculi treated with extracorporeal shock wave lithotripsy in our hospital from March 2013 to March 2015, who were randomly divided into group A, group B and C group (n=104 cases). The patients in group A were taken modified stone soup, diclofenac and nifedipine; patients in group B were given tamsulosin hydrochloride sustained release tablets, patients in group C were used tamsulosin hydrochloride sustained release capsules. The rate of stone drainage, incidence of renal colic and degree of pain of three groups were observed and compared. Results: The rate of stone drainage of group B and group C were significantly higher than that in group A after treatment 3 d, 1 week, 2 weeks and 4 weeks, and the incidence of renal colic and degree of pain in two groups were significantly better in the first division, with statistical significance (P<0.05). The rate of stone drainage and incidence of renal colic in group C were significantly better than that in group B after treatment 3 d, with statistical significance (P<0.05). Conclusion: Tamsulosin hydrochloride sustained-release capsules and tamsulosin hydrochloride sustained release capsules can get good results for the treatment of ureteral calculi. But tamsulosin hydrochloride sustained-release capsules have more rapid effect, more significant inhibition in the occurrence of renal colic, and satisfactory clinical safety.