Objective: To explore the clinicopathological features, diagnosis, and differential diagnosis of epithelioid angiosarcoma (EA). Methods: The clinical diagnosis and treatment data of 10 EA patients admitted to First Affiliated Hospital of Bengbu Medical College from January 2010 to December 2019 were analyzed, and the histopathological morphology and immunohistochemical characteristics were observed and analyzed. Results: Of the 10 cases, 8 were male and 2 were female. The sites were neck (2 cases), chest wall (2 cases), pancreas (1 case), perineum (1 case), testicles (1 case), buttocks (1 case), ankles (1 case) and ribs (1 case). Microscopically, the tumor cells were diffused into sheets or clustered into nests, and irregular vascular-like Spaces of varying sizes were seen in the tumor tissue. Tumor cells have epithelioid characteristics, large cells, round, spindle or polygon, abundant cytoplasm eosinophilic, nucleoli obvious. Immunophenotype showed that CD31 and ERG were positive in tumor cells, and CD34 and FLI-1 were positive in most cases. All patients received surgical treatment, and 7 patients were followed up after surgery for 2–60 months. Six patients died and 1 patient survived without disease progression. Conclusion: EA is a highly malignant sarcoma, which is prone to misdiagnosis or missed diagnosis. It has certain morphological similarities with metastatic carcinoma, epithelioid hemangioendothelioma, malignant melanoma, and epithelioid sarcoma, Immunohistochemical tests are helpful in differentiating the diagnosis.