Objective: To explore the effect of group social skills training in patients with chronic schizophrenia. Methods: A total of Select 148 patients with chronic schizophrenia admitted to our hospital from January 2019 to July 2020. The double-blind, randomized clinical trial design was adopted, and the random number table method was used to divide them into two groups. During the follow-up of 3 months, 2 cases were dropped out, and 146 cases were finally included as the research objects. The control group (73 cases) underwent routine rehabilitation training, and the observation group (73 cases) performed group social skills training on this basis. The severity of psychiatric symptoms, social function deficits, compliance behavior and rehabilitation efficacy were compared between the two groups. Results: After 3 months of intervention, the Positive and Negative Syndrome Scale (PANSS) score of the observation group was lower than that of the control group (P<0.05); the Social Disability Screening Schedule (SDSS) score of the observation group was lower than that of the control group (P<0.05); the observation group’s compliance behavior was better than that of the control group (P<0.05); the Inpatient Psychiatric Rehabilitation Outcome Scale (IPROS) score of the observation group was lower than that of the control group (P<0.05). Conclusion: Group social skills training applied to patients with chronic schizophrenia can effectively relieve their mental symptoms, improve social function deficits and compliance behaviors, and improve rehabilitation efficacy.