Objective: To study the effect of group biofeedback therapy and psychological nursing in convalescence of schizophrenia. Methods: A total of 120 patients with schizophrenia admitted to our hospital from July 2020 to March 2021 were selected, they were randomly divided into an observation group and a control group by random number table method, with 60 cases in each group. The control group received routine nursing, and the observation group was given group biofeedback therapy combined with psychological nursing. Both groups were treated for 8 weeks. The clinical efficacy after 8 weeks of treatment, the Positive and Negative Syndrome Scale (PANSS) score, Nurses’ Observation Scale for Inpatient Evaluation (NOSIE-30) score, Inpatient Psychiatric Rehabilitation Outcome Scale (IPROS) score before and after 8 weeks of treatment, and treatment compliance of the two groups were compared. Results: Compared with the control group, the total effective rate in the observation group was higher (P<0.05); after treatment, the positive factors, negative factors, general psychopathology scores and total scores of the PANSS score, NOSIE-30 score and IPROS score in two groups were significantly lower than that of before treatment, and compared with the control group, the positive factors, negative factors, general psychopathology scores and total scores of the PANSS score NOSIE-30 score and IPROS score in the observation group patients were lower (P<0.05). Compared with the control group, the treatment compliance rate in the observation group was higher (P<0.05). Conclusion: The effect of group biofeedback therapy and psychological nursing in convalescent schizophrenia is obvious, which is worthy of clinical application.