Objective: To compare the effect of artificial dermis and skin flap in repairing fingertip soft tissue defect. Methods: Eighty-six patients (86 fingers) with fingertip soft tissue defect in our hospital from May 2019 to April 2021 were selected and divided into two groups according to the treatment methods, with 43 cases in each group. The control group was treated with pedicled flap repair, and the observation group was treated with artificial dermal repair. The skin flap(graft) survival rate, wound healing, scar hyperplasia, finger function recovery and patient satisfaction were compared between the two groups. Results: The skin flap(graft) survival rate in the observation group and the control group was 93.02% and 90.70% respectively, and the difference was not statistically significant (P>0.05). There was no significant difference in the excellent and good rate of wound healing between the two groups (P>0.05), but the wound healing time in the observation group was significantly shorter than that in the control group (P<0.05), and the Vancouver Scar Scale (VSS) score at 3 months and 6 months after operation in the observation group was significantly lower than that in the control group (P<0.05). There was no significant difference in two-point discrimination and hand function scores between the two groups at 3 and 6 months after operation (P>0.05). The satisfaction of the observation group was significantly higher than that of the control group (P<0.05). Conclusion: The effect of artificial dermis in repairing soft tissue defect of fingertip is significant, with small damage and high aesthetic value, which is worthy of clinical application.