文章摘要

长链非编码RNA调控肿瘤细胞凋亡的研究进展

作者: 1梁亚雪, 1唐圣松
1 南华大学药物药理研究所，湖南 衡阳 421001
通讯: 唐圣松 Email: tangss111@163.com
DOI: 10.3978/j.issn.2095-6959.2016.05.028
基金: 湖南省高校科技创新平台开放基金, 09K072，12K120

摘要

长链非编码RNA(long non-coding RNA，lncRNA)是一类长度>200个核苷酸、通常不编码蛋白质的RNA。近年研究表明，lncRNA在肿瘤的的发展过程中发挥抑癌或促癌作用，参与细胞增殖、凋亡等过程。本综述简要介绍lncRNA的生物学功能及其调控细胞凋亡的研究进展。
关键词： 长链非编码RNA 细胞凋亡 肿瘤

Progress of long non-coding RNA in regulating apoptosis of tumor cells

Authors: 1LIANG Yaxue, 1TANG Shengsong
1 Institute of Pharmacy and Pharmacology, University of South China, Hengyang Hunan 421001, China

CorrespondingAuthor: TANG Shengsong Email: tangss111@163.com

DOI: 10.3978/j.issn.2095-6959.2016.05.028

Abstract

Long non-coding RNA is a kind of RNA that is more than 200 nucleotides in transcript length and non-protein coding RNA. In the recent years, data have shown that lncRNA plays an important role in the development of tumor by suppressing or promoting cancer, and involves in regulating cell apoptosis and proliferation. This review briefly introduces the function of lncRNA, and summarizes progress of lncRNA in regulating apoptosis of tumor cells.

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