弥散张量成像在缺陷型精神分裂症患者认知功能评估中的应用
| 作者: |
1吴雪峰,
2陈丽,
1徐华,
1邵宝富
1 淮安市第三人民医院影像科，江苏 淮安 223001 2 淮安市第三人民医院功能科，江苏 淮安 223001 |
| 通讯: |
陈丽
Email: chengcheng8667@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.03.024 |
摘要
目的：探讨弥散张量成像(diffusion tensor imaging，DTI)在缺陷型精神分裂症患者认知功能评估中的应用价值。方法：选取2019年6月至2021年6月淮安市第三人民医院缺陷型精神分裂症患者68例为研究组，另选取同期健康体检者39例为对照组。所有受检者均接受影像学检查，测定左侧大脑脚、右侧额叶、左侧内囊前肢、胼胝体膝部、胼胝体压部各向异性分数(anisotropy score，FA)，并通过精神分裂症认知功能成套测验(MATRICS Consensus Cognitive Batter，MCCB)评估受检者认知功能。记录两组DTI检查不同脑区FA值和MCCB结果，并统计分析研究组不同脑区FA值与MCCB各维度分值间的关联性。结果：研究组左侧大脑脚、右侧额叶、左侧内囊前肢、胼胝体膝部、胼胝体压部FA值均小于对照组，差异均有统计学意义(均P<0.05)；研究组情绪管理、迷宫、视觉记忆、言语记忆、空间广度、数字序列、持续操作测试、语义流畅性、符号编码、连线测试评分均低于对照组，差异均有统计学意义(均P<0.05)；左侧大脑脚、右侧额叶、左侧内囊前肢、胼胝体膝部、胼胝体压部FA值与情绪管理、迷宫、视觉记忆、言语记忆、空间广度、数字序列、持续操作测试、语义流畅性、符号编码、连线测试评分间均呈正相关(均P<0.05)。结论：通过DTI检查可明确缺陷型精神分裂症患者的大脑白质纤维结构异常情况，且异常状况和患者认知功能状态存在密切关联，临床上可通过DTI检查评估缺陷型精神分裂症患者的认知功能，并指导进行针对性干预。
关键词：
弥散张量成像；缺陷型精神分裂症；认知功能
Application of diffusion tensor imaging in cognitive function evaluation of patients with deficit schizophrenia
CorrespondingAuthor: CHEN Li Email: chengcheng8667@126.com
DOI: 10.3978/j.issn.2095-6959.2022.03.024
Abstract
Objective: To explore the application value of diffusion tensor imaging (DTI) in the evaluation of cognitive function in patients with deficit schizophrenia. Methods: Sixty-eight patients with deficit schizophrenia in Third People’s Hospital of Huai’an from June 2019 to June 2021 were selected as a study group, and 39 healthy subjects during the same period were selected as a control group. All subjects underwent imaging examinations to measure the anisotropy scores (FA) of the left cerebral foot, right frontal lobe, left internal capsule forelimb, corpus callosum knee, and corpus callosum pressure. The test suite [MATRICS Consensus Cognitive Batter (MCCB)] assesses the cognitive function of the subject. The FA values and MCCB test results of different brain areas in the 2 groups were counted, and the correlation between the FA values of different brain areas and the scores of each dimension of MCCB in the study group was analyzed. Results: The FA values of the left cerebral foot, right frontal lobe, left internal capsule forelimb, corpus callosum knee, and corpus callosum pressure in the study group were lower than those of the control group, and the difference was statistically significant (all P<0.05). The scores of emotion management, maze, visual memory, verbal memory, spatial span, number sequence, continuous operation test, semantic fluency, symbol coding and connecting test in the study group were lower than those in the control group, and the differences were statistically significant (all P<0.05). The FA values of left cerebral foot, right frontal lobe, left internal capsule forelimb, corpus callosum knee and corpus callosum pressure were positively correlated with the scores of emotion management, maze, visual memory, verbal memory, spatial span, number sequence, continuous operation test, semantic fluency, symbol coding, and connection test (all P<0.05). Conclusion: DTI examination can be used to identify the abnormalities of white matter fiber structure in patients with deficit schizophrenia, and there is a close correlation between the abnormalities and the cognitive function of patients. In clinical practice, DTI examination can be used to evaluate the cognitive function of patients with deficit schizophrenia, and to guide the clinical intervention.
Keywords：
diffusion tensor imaging; deficit schizophrenia; cognitive function