慢性阻塞性肺疾病急性加重期患者肠道微生态环境与肺功能、血气分析的相关性
| 作者: |
1杨妍,
1朱涛峰,
1王阳,
1朱勤,
1马秀琴
1 江苏大学附属宜兴医院呼吸与危重症医学科，江苏 无锡 214200 |
| 通讯: |
马秀琴
Email: fgruhjuy@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.03.008 |
摘要
目的：探讨慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease，AECOPD)患者肠道微生态环境与肺功能、血气指标的关联性。方法：选取2019年1月1日至2020年12月31日于江苏大学附属宜兴医院呼吸与危重症医学科门诊及病房收治的AECOPD患者96例为研究组，另选取同期健康体检者96例为对照组。所有受检者入院后均测定肺功能，并抽取粪便样本测定肠道微生态环境相关指标、抽取血液样本测定动脉血气指标水平。统计两组肠道微生态环境相关指标水平、肺功能及血气指标水平，并统计分析肠道微生态环境相关指标与肺功能、血气指标的关联性。结果：研究组大肠埃希菌水平与对照组相比，差异无统计学意义(P>0.05)，研究组双歧杆菌、乳酸杆菌水平低于对照组，粪肠球菌、屎肠球菌水平高于对照组(P<0.05)。研究组第1秒用力呼气末容积(1 s forced end-expiratory volume，FEV1)、FEV1占预计值百分比(FEV1 as a percentage of projected，FEV1%pred)、FEV1/FVC、PaO2水平低于对照组，PaCO2水平高于对照组(P<0.05)。经Pearson检验可知，双歧杆菌、乳酸杆菌水平与FEV1、FEV1%pred、FEV1/FVC、PaO2水平呈正相关、与PaCO2水平呈负相关，粪肠球菌、屎肠球菌水平与FEV1、FEV1%pred、FEV1/FVC、PaO2水平呈负相关、与PaCO2水平呈正相关(均P<0.05)。结论：AECOPD患者存在肠道微生态环境紊乱，且肠道微生态环境紊乱程度和肺功能、血气状态存在密切关联性。
关键词：
慢性阻塞性肺疾病急性加重期；肠道微生态环境；肺功能；血气指标；关联性
Correlation of intestinal microecological environment and lung function with blood gas analysis in patients with acute exacerbation of chronic obstructive pulmonary disease
CorrespondingAuthor: MA Xiuqin Email: fgruhjuy@163.com
DOI: 10.3978/j.issn.2095-6959.2022.03.008
Abstract
Objective:To investigate the relationship of intestinal microecological environment and lung function with blood gas index in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: From January 1, 2019 to December 31, 2020, 96 patients with AECOPD in the outpatient and ward of the Department of Respiratory and Critical Medicine of Yixing Hospital Affiliated to Jiangsu University were selected as a study group, and 96 healthy physical examiners in the same period were selected as a control group. Pulmonary function was measured in all subjects after the admission, stool samples were taken to measure intestinal microecological environment-related indicators, and blood samples were drawn to measure arterial blood gas index levels. The levels of intestinal microecological environment-related indexes, lung function and blood gas indexes in the 2 groups were statistically analyzed, and the correlation of intestinal microecological environment-related indexes with lung function and blood gas indexes was statistically analyzed. Results: There was no significant difference in Escherichia coli level between the study group and the control group (P>0.05); the levels of Bifidobacterium and Lactobacillus in the study group were lower than those in the control group, and the levels of Enterococcus faecalis and Enterococcus faecium were higher than those in the control group (P<0.05). The levels of FEV1, FEV1%pred, FEV1/FVC and PaO2 in the study group were lower than those in the control group, while the PaCO2 levels were higher than those in the control group (P<0.05). Pearson test showed that the levels of Bifidobacterium and Lactobacillus were positively correlated with the levels of FEV1, FEV1%pred, FEV1/FVC and PaO2, and negatively correlated with the levels of PaCO2. The levels of Enterococcus faecalis and Enterococcus faecium were negatively correlated with the levels of FEV1, FEV1%pred, FEV1/FVC and PaO2, but positively correlated with the levels of PaCO2 (P<0.05). Conclusion: AECOPD patients have intestinal microecological environment disorder, and there is a close correlation of the degree of intestinal microecological environment disorder with pulmonary function and blood gas status.
Keywords：
acute exacerbation of chronic obstructive pulmonary disease; intestinal microecological environment; lung function; blood gas index; correlation