文章摘要

VEGF-C 与VEGF-D 比值变化与肿瘤淋巴道转移的研究进展

作者: 1王静文, 2唐建武, 1张玉琳, 1应志国
1 宁波卫生职业技术学院医学技术学院，浙江 宁波 315100
2 大连医科大学病理学教研室，辽宁 大连 116044
通讯: 王静文 Email: wangjingwen1366@163.om
基金: 宁波卫生职业技术学院科研课题(201305)

摘要

肿瘤侵袭周边原有淋巴管以及诱导组织内新生淋巴管的形成，是肿瘤淋巴道转移的必要条件。VEGF-C和VEGF-D是特异性淋巴管生长调节因子，与淋巴管的增生和分化密切相关。二者的比值升高可能是肿瘤淋巴道转移的早期事件和潜在评估指标。本文介绍VEGF-C和VEGF-D的结构、功能、比值变化以及二者与肿瘤淋巴道转移关系的研究进展。
关键词： VEGF-C；VEGF-D；肿瘤；淋巴道转移

Changes in the ratio of VEGF-C to VEGF-D and tumor lymphatic metastasis

Authors: 1WANG Jingwen, 2TANG Jianwu, 1ZHANG Yulin, 1YING Zhiguo
1 School of Medical Technology, Ningbo College of Health Sciences, Ningbo Zhejiang 315100
2 Department of Pathology, Dalian Medical University, Dalian Liaoning 116044, China

CorrespondingAuthor: WANG Jingwen Email: wangjingwen1366@163.om

Abstract

Invasion of the surrounding original lymphatic vessel and induction of the lymphangiogenesis formation are the necessary conditions for tumor lymphatic metastasis. VEGF-C and VEGF-D are specific lymphatic growth regulators, which are closely related to the development and differentiation of lymphatic vessels. The increase of the ratio of VEGF-C to VEGF-D might be the early event and a potential evaluation index for tumorigenesis and lymphatic metastasis. This review focuses on the research progress in the structure, function and the ratio of VEGF-C to VEGF-D. The correlation between ratio of VEGF-C to VEGF-D and the tumor lymphatic metastasis is also discussed.

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