Objective: To explore the effect of “Internet Plus” remote management mode based on multidisciplinary diabetes care team (MDCT) on treatment compliance, blood glucose control, quality of life and pregnancy outcome in gestational diabetes mellitus (GDM) patients. Methods: A total of 140 patients with GDM from January 2019 to December 2020 were selected as the research object and were randomly divided into control group and study group, with 70 cases in each group. The “Internet Plus” remote management mode based on MDCT was built. The control group was managed by MDCT management mode, while based on MDCT management mode of the control group, the research group adopted the “Internet Plus” based on individual remote management mode. Before intervention and one week before delivery, the compliance of the two groups was assessed by the compliance scale of diabetes treatment, the blood glucose levels were monitored between the two groups and the blood glucose compliance rate was calculated, the quality of life of the 2 groups were assessed by the Short-Form 36-item (SF-36) health survey, and then the changes and differences of the above indicators between the two groups before and after the intervention were compared. After pregnancy, the pregnancy outcomes of the 2 groups and the patients’ satisfaction with the intervention methods were compared. Results: By the end of the study, 7 cases in each group had been lost to follow-up. After the intervention, the treatment compliance scores in the five dimensions of medication, diet, exercise, self-monitoring, and regular review and the total scores in the 2 groups were significantly higher than those before the intervention (P<0.05 or P<0.001), and the improvement degrees in the study group were significantly higher than those in the control group (P<0.05 or P<0.001). The good treatment compliance rate of the study group was 90.48%, which was significantly higher than that of the control group (42.86%) (P<0.001). The levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG) and glycosylated hemoglobin (HbA1c) level in the 2 groups were significantly improved after intervention (all P<0.001), and the improvement degrees of the study group were significantly better than those of the control group (P<0.05 or P<0.001). After the intervention, the compliance rate of blood glucose in the control group was 9.52%, which was significantly higher than that in the control group (P=0.036). After the intervention, the scores of overall health and mental health in the control group decreased significantly (all P<0.05), but the above scores in the study group were significantly higher than those before the intervention and higher than those in the control group (all P<0.05); the scores of vitality and social function in the 2 groups decreased significantly after intervention (all P<0.001), but the degrees of reduction in the study group were significantly lower than those in the control group (P<0.05 or P<0.001). The incidence of polyhydramnios, neonatal hypoglycemia and fetal growth restriction in the study group were significantly lower than those in the control group (all P<0.05). However, there were no significant differences in the incidence of premature rupture of membranes, preterm delivery, macrosomia, and neonatal respiratory distress between the 2 groups (all P>0.05). According to the intervention methods, the patients’ satisfaction score in the study group was significantly higher than that in the control group (P<0.05). Conclusion: The “Internet Plus” remote management mode based on MDCT for GDM patients can improve the treatment compliance, the blood glucose control level, and quality of life, and reduce the incidence of maternal and infant complications, so it has satisfactory effect and is worthy of promotion.