Objective: To study the intervention effect of rehabilitation nursing based on failure modes and effects analysis (FMEA) model on patients with coronary heart disease and arrhythmia. Methods: A total of 100 patients with coronary heart disease complicated with arrhythmia treated in our hospital from January 2020 to June 2021 were selected and divided into an experimental group and a control group by random number table method, with 50 cases in each group. The patients in the control group were given routine nursing, and the patients in the experimental group were given rehabilitation nursing based on FMEA model. All of them were treated from admission to discharge. The clinical efficacy, changes of Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), 36-item Short-Form (SF-36) and nursing satisfaction were compared between the two groups at discharge. Results: After nursing, the HAMA and HAMD scores in the experimental group were lower than that of the control group, the difference was statistically significant (P<0.05); each item scores of the SF-36 in experimental group were significantly higher than that of control group, the difference was statistically significant (P<0.05); compared with the control group, the total satisfaction rate of nursing in the experimental group was higher (P<0.05). Conclusion: Rehabilitation nursing based on FMEA model have obvious intervention effect on patients with coronary heart disease complicated with arrhythmia, which can effectively improve patients’ bad mood, quality of life, improve the nursing satisfaction, which is worthy of clinical promotion.