文章摘要

非小细胞肺癌中的循环肿瘤细胞

作者: 1Boshuizen Rogier, 2Kuhn Peter, 1Heuvel Michel van den
1 Department of Thoracic Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
2 Department of Cell Biology, The Scripps Research Institute, 10666 North Torrey Pines Road, GAC-1200, La Jolla, CA 92037, USA
通讯: Boshuizen Rogier Email: r.boshuizen@nki.nl

摘要

肺癌是世界上最致命的癌症类型。仅仅在美国，每年就有超过225000人被确诊为肺癌，2012年预计死于肺癌的患者大约有16万。与癌胚抗原(carcinoembryonic antigen，CEA)在结肠癌以及前列腺特异抗原(prostate specific antigen，PSA)在前列腺癌中的作用不同，在肺癌患者诊治过程中，肿瘤标志物的应用并不广泛。肺癌的诊断依赖于影像学检查，而不是体液中的肿瘤标志物。然而在最近的研究中，循环肿瘤细胞(circulating tumor cells，CTCs)的潜在价值被发现。基于CTCs的分析已经被视作“液相活组织检查”，它将有助于我们对恶性肿瘤进行定性和定量的分析
关键词： 非小细胞肺癌 循环肿瘤细胞

Circulating tumor cells in non-small cell lung carcinoma

Authors: 1Rogier Boshuizen, 2Peter Kuhn, 1Michel van den Heuvel
1 Department of Thoracic Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
2 Department of Cell Biology, The Scripps Research Institute, 10666 North Torrey Pines Road, GAC-1200, La Jolla, CA 92037, USA

CorrespondingAuthor: Rogier Boshuizen Email: r.boshuizen@nki.nl

Abstract

Circulating tumor cells (CTCs) are associated with survival of cancer patients. Several methods have been developed to detect circulating tumor cells. The number of CTCs in NSCLC is lower than in other solid tumors. To date, trials are ongoing for a better understanding of CTCs. Besides association with prognosis, CTCs can be used to assess the efficacy of treatment and they are important substrates for molecular profiling of the tumor.

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