双特异性蛋白磷酸酶6在肿瘤中作用的研究进展
| 作者: |
1冯琨,
1肖明明,
1景士兵
1 辽宁省人民医院病理科，沈阳 110016 |
| 通讯: |
景士兵
Email: jingsb777@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.02.016 |
摘要
双特异性蛋白磷酸酶6(dual specificity phosphatases 6，DUSP6)是一种双特异性蛋白磷酸酶，主要是负反馈调控反转录病毒相关的DNA序列-细胞外信号调节激酶1/2(retrovirus associated DNA sequences-extracellular signal regulated kinase，RAS-ERK1/2)信号通路。而DUSP6对于RAS-ERK1/2信号转导通路的负反馈调节一旦打破，就可能会引起肿瘤，甚至还会出现恶性分化。近年来DUSP6在肿瘤形成、浸润、转移和肿瘤治疗方面的作用，已成为新的研究热点，能有助于许多恶性肿瘤的临床病理的诊断及治疗预后的判断。
关键词：
双特异性蛋白磷酸酶6；促分裂原活化蛋白激酶；ERK；肿瘤
Progress in study on DUSP6 in the tumor
CorrespondingAuthor: JING Shibing Email: jingsb777@163.com
DOI: 10.3978/j.issn.2095-6959.2014.02.016
Abstract
Dual specificity protein phosphatase 6(DUSP6 ) is a dual specificity protein phosphatase, which exerts an important negative feedback effect on retrovirus associated DNA sequences-extracellular signal regulated kinase (RAS-ERK1/2) signaling pathway. Once the negative feedback regulation is broken, it may cause cancer, or even malignant differentiation. In recent years, DUSP6 has become a new hotspot in tumor formation, invasion, metastasis and treatment, which may have value in clinical diagnosis and prognosis for many malignant tumors.