文章摘要

泛素蛋白酶体碳末端水解酶L3

作者: 1武静, 2师永红
1 内蒙古医科大学 病理学中心；附属第一医院病理科，呼和浩特 010059
2 内蒙古医科大学 病理学中心； 附属第一医院病理科，呼和浩特 010059
通讯: 师永红 Email: 1351481527@163.com
DOI: 10.3978/j.issn.2095-6959.2014.02.013
基金: 国家自然科学基金, 81360395

摘要

泛素蛋白酶体碳末端水解酶L3(Ubiquitin C-terminal hydrolases L3，UCH-L3)是泛素蛋白酶体中碳末端水解酶的一种，可以将泛素分子从底物上水解下来，使得泛素蛋白酶体在细胞内再循环利用。目前对UCH-L3的研究还不充分，近年来发现它在多种疾病中都呈现高表达，可能与多种疾病的发生和发展有一定的联系。
关键词： 泛素蛋白酶体碳末端水解酶L3；肿瘤；疾病

Ubiquitin C-terminal hydrolase L3

Authors: 1WU Jing, 2SHI Yonghong
2 Department of Pathology, Inner Mongolia Medical University; Department of Pathology, First Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China

CorrespondingAuthor: SHI Yonghong Email: 1351481527@163.com

DOI: 10.3978/j.issn.2095-6959.2014.02.013

Abstract

Ubiquitin C-terminal hydrolases L3 (UCH-L3) is a C-terminal hydrolase in ubiquitin-proteasome. Ubiquitin can be hydrolyzed from the substrate, so that the ubiquitin-proteasome can be recycled in the cells. In recent years, scientists have found that UCH-L3 highly expressed in several diseases such as neoplasms, obesity, etc., which may be related to the occurrence and development of these diseases.

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