Objective: To observe the clinical efficacy of individualized postoperative care for patients undergoing oral cancer surgery. Methods: A total of 60 patients undergoing oral cancer surgery in our hospital were selected and divided into a control group and an observation group (50 cases in each group). Patients in the observation group received individualized postoperative care, while patients in the control group received routine postoperative care. The incidence of complications, quality of life and changes of indicators were recorded in the two groups. Results: The score of quality of life, treatment compliance and satisfaction in the observation group were higher than those in the control group, while the length of hospital stay and incidence of complications were significantly lower than those in the control group, and the results of the two groups were statistically significant (P<0.05). Conclusion: Individualized postoperative intervention can improve the survival quality score, treatment compliance and satisfaction of patients undergoing oral cancer surgery, as well as shortening the hospitalization stay and reducing the incidence of complications.