Objective: This paper means to awake the physical examination and health management organizations to pay more attention to the results explanation by analyzing the effectiveness of health intervention effect of face-to- face results explanation. Methods: We retrospectively analyzed 689 healthy subjects who have received at least two consecutive health examinations in the Shanghai Jiao Tong University School of Medicine affiliated Ruijin Hospital. The subjects were divided into a replied group (n=509) and a non-replied group (n=180) by whether or not receiving face-to-face results explanation. We compared the medical indexes which can be somehow influenced by life style improvement or medical intervention, so as to analyze the influence of face-to-face results explanation on health managing intervention. Results: We found no statistically significant differences between these two groups in sex, age, height, body mass index (BMI) and education level (P>0.05). The replied group showed more advantage in improving impaired glucose tolerance, hypertriglyceridemia, hepatic insufficiency and Helicobacter pylori eradication (P<0.05); the new morbidity of impaired glucose tolerance, intrahepatic fatty infiltration, atherosclerosis and hyperuricemia were significantly lower in the replied group than in the non-replied group (P<0.05). Conclusion: Face-to-face results explanation shows positive effect on improving health management intervention, which may strengthen the self-health management and reduce medical expenditure.