Objective: To analyze the influence of conventional radiotherapy and conformal intensity modulated radiotherapy (IMRT) on recurrence rate and metastasis rate of patients with intermediate to advanced cervical cancer. Methods: A total of 102 patients with intermediate to advanced cervical cancer treated in Obstetrics and Gynecology Hospital, Nanjing Medical University from January 2015 to December 2018 were included in this study. They were divided into a control group (conventional radiotherapy, n=51) and a treatment group (three-dimensional conformal IMRT, n=51) by computer blind selection method. The expression levels of serum tumor markers and serum indexes of the two groups were compared and analyzed, and the long-term efficacy and adverse reactions of the two groups were counted. Results: In squamous epithelial antigen (SCCA), carcinoembryonic antigen (CEA), carbohydrate antigen 724 (CA724) and carbohydrate antigen 199 (CA199) levels, the treatment group was lower than the control group (P<0.05). In vascular endothelial growth factor C (VEGFC), CD44v6, transforming growth factor β1 (TGF-β1) and matrix metalloproteinase 9 (MMP9), the treatment group were lower than the control group (P<0.05). In the 1-year survival rate, 2-year survival rate, local recurrence rate and distant metastasis rate, the treatment group was better than the control group (P<0.05). The incidence of adverse reactions in treatment group was lower than that in control group (P<0.05). Conclusion: The effects of three-dimensional modulated intensity modulated radiation therapy for intermediate and advanced cervical cancer is ideal, which can promote the improvement of the expression level of serum tumor markers, reduce immune function damage, regulate serum indicators, reduce tumor recurrence and metastasis, and prolong the survival time. It can be further popularized in clinic.