急性脑出血患者血清HIF-1α与VEGF、Hsp70动态表达情况研究
| 作者: |
1岑丽霞,
1靳敏,
1袁汝康
1 中山市广济医院神经内科，广东 中山 528427 |
| 通讯: |
岑丽霞
Email: ceilixia1982@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.08.025 |
摘要
目的：研究分析急性脑出血患者血清低氧诱导因子(hypoxia-inducible factor-1α，HIF-1α)与血管生长因子(vascular endothelial growth factor，VEGF)、热休克蛋白70(heat shock protein 70，Hsp70)动态表达情况。方法：将2014年3月至2015年4月我院急诊收治的35例急性脑出血患者，根据其出血量分为小量组、中量组、大量组，测定比较各分组人员发病后12 h、1 d、3 d、5 d、7 d的静脉血HIF-1α与VEGF、Hsp70差异，同时研究分析这3者与出血量之间的相关关系。结果：大量组患者不同时间点HIF-1α与VEGF、Hsp70指标均明显高于同时间点其他两组患者，P<0.05；单因素方差分析HIF-1α与VEGF、Hsp70与患者出血量间关系，均成正相关(r=0.563，P<0.05；r=0.771，P<0.05；r=0.602，P<0.05)。结论：HIF-1α、VEGF、Hsp70在急性脑出血患者中表达较高，在脑出血12 h后升高，并随着脑出血的发展呈现动态表达，且与出血量成正相关关系。
关键词：
急性脑出血
低氧诱导因子-1α
血管生长因子
热休克蛋白70
The study of HIF-1α and VEGF, Hsp70 dynamics expression with acute cerebral hemorrhage patients
CorrespondingAuthor: CEN Lixia Email: ceilixia1982@163.com
DOI: 10.3978/j.issn.2095-6959.2016.08.025
Abstract
Objective: To study hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF), heat shock protein 70 (Hsp70) dynamics expression with acute cerebral hemorrhage patients.
Methods: 35 acute cerebral hemorrhage patients in our emergency department from March 2014 to April 2015 were selected, divided the patients into small group, middle group, large group according to the amount of bleeding, determined and compared the difference of blood HIF-1α and VEGF, Hsp70 of patients after the onset of 12 h, 1 d, 3 d, 5 d, 7 d, and analyzed the relationship among the bleeding amount between the three groups. Results: The HIF-1α and VEGF, Hsp70 indicators of large group patients at different time were significantly higher than those at the same time in the other two groups, P<0.05; ANOVA between HIF-1α and VEGF, Hsp70 and the amount of bleeding in patients relationship, all positive related (β=0.012, P<0.05; β=0.146, P<0.05; β=0.943, P<0.05). Conclusion: HIF-1α, VEGF, Hsp70 expression in acute cerebral hemorrhage patients were at a high stage, and at 12 h after cerebral hemorrhage increased, dynamic expressed with the development of cerebral hemorrhage presents, and positively related to the bleeding amount.
Methods: 35 acute cerebral hemorrhage patients in our emergency department from March 2014 to April 2015 were selected, divided the patients into small group, middle group, large group according to the amount of bleeding, determined and compared the difference of blood HIF-1α and VEGF, Hsp70 of patients after the onset of 12 h, 1 d, 3 d, 5 d, 7 d, and analyzed the relationship among the bleeding amount between the three groups. Results: The HIF-1α and VEGF, Hsp70 indicators of large group patients at different time were significantly higher than those at the same time in the other two groups, P<0.05; ANOVA between HIF-1α and VEGF, Hsp70 and the amount of bleeding in patients relationship, all positive related (β=0.012, P<0.05; β=0.146, P<0.05; β=0.943, P<0.05). Conclusion: HIF-1α, VEGF, Hsp70 expression in acute cerebral hemorrhage patients were at a high stage, and at 12 h after cerebral hemorrhage increased, dynamic expressed with the development of cerebral hemorrhage presents, and positively related to the bleeding amount.