Objective: To explore the intervention effect of oral exercise training combined with non-nutritive sucking on infant swallowing dysfunction. Methods: From January 2020 to May 2021, 104 infants with swallowing dysfunction treated in the Pediatric Intensive Care Unit (PICU) of Hainan Provincial People’s Hospital were enrolled and randomly divided into a control group and a study group by random number table method, with 52 cases in each group. The control group was given routine intervention of non-nutritive sucking and the study group carried out oral exercise training combined with non-nutritive sucking intervention. The recovery effect of dysphagia in infants of the 2 groups was observed. Results: The recovery time of dysphagia and the total hospital stay in the study group were significantly shorter than those in the control group (both P<0.001). After 3 and 7 days of intervention, the amount of milk sucked by mouth in 10 min was significantly higher than that before intervention in both groups (both P<0.001). The amount of milk sucked by mouth in 10 min in the study group was also significantly higher than that in the control group (P<0.001). After 3 and 7 days of intervention, the sucking proficiency of the 2 groups was higher than that before intervention (both P<0.001), and the sucking proficiency of the study group was higher than that of the control group (P<0.01). Conclusion: The intervention of oral exercise training combined with non-nutritional sucking for infants with swallowing dysfunction can significantly improve the amount of milk sucked through the mouth and the proficiency of sucking, and shorten the recovery time of swallowing disorder and the total length of hospital stay.