RhE阴性受者输注同型与非同型血的短期免疫功能变化
| 作者: |
1吕建春,
2梁晓峰
1 延安市人民医院输血科，陕西 延安 716000 2 榆林市中心血站检验科，陕西 榆林 719000 |
| 通讯: |
梁晓峰
Email: 1065423949@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.01.009 |
摘要
目的：探究供血者Rh血型E抗原阳性、阴性对患者体液免疫和细胞免疫的影响。方法：收集2019年10月至2020年10月延安市人民医院收治需输血治疗的患者60例，按照患者入组顺序进行编号，单数为观察组(n=30)，双数为对照组(n=30)，对所有Rh血型E抗原阴性患者进行输血，对照组患者输入Rh血型E抗原阴性血，观察组患者输入Rh血型E抗原阳性血。比较2组患者体液免疫[免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)]、细胞免疫[CD3+、CD4+、CD8+]、炎症因子[白细胞介素-2(IL-2)、白细胞介素-4(IL-4)]水平及不良反应发生情况。结果：不同时间点IgG、IgA、IgM水平差异有统计学意义(P<0.05)，观察组IgG、IgA、IgM水平明显低于对照组(P<0.05)，2组IgG、IgA、IgM水平变化趋势差异有统计学意义(P<0.05)；不同时间点CD3+、CD4+、CD8+水平差异有统计学意义(P<0.05)，观察组CD3+、CD4+、CD8+水平明显低于对照组(P<0.05)，2组CD3+、CD4+、CD8+水平变化趋势差异有统计学意义(P<0.05)；不同时间点IL-2、IL-4水平差异有统计学意义(P<0.05)，观察组IL-2、IL-4水平明显低于对照组(P<0.05)，2组IL-2、IL-4水平变化趋势差异有统计学意义(P<0.05)；观察组不良反应总发生率略高于对照组(13.33% vs 6.67%，P>0.05)。结论：给予Rh血型E抗原阴性患者输注阳性血后，患者体液免疫和细胞免疫指标水平均明显下降，会促进炎症因子的释放，但无其他不良反应。
关键词：
Rh血型；E抗原；体液免疫；细胞免疫
Short-term immune function changes of RhE negative recipients after infusion of homotypic and non-homotypic blood
CorrespondingAuthor: LIANG Xiaofeng Email: 1065423949@qq.com
DOI: 10.3978/j.issn.2095-6959.2022.01.009
Abstract
Objective: To explore the effects of positive and negative Rh blood group E antigen of donors on patients’ humoral and cellular immunity. Methods: A total of 60 patients treated in our hospital who needed blood transfusion from October 2019 to October 2020 were collected. According to the order of patients included in the group, patients with the odd number were assigned into the observation group (n=30), and patients with the even number were included into the control group (n=30). Blood transfusion was performed on all patients with negative Rh blood group E antigen. Patients in the control group were given Rh blood group E antigen negative blood, while patients in the observation group were given Rh blood group E antigen positive blood. The levels of humoral immunity [immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM)], cellular immunity [CD3+, CD4+ and CD8+], inflammatory factors [interleukin-2 (IL-2), interleukin-4 (IL-4)] and the occurrence of adverse reactions were compared between the 2 groups. Results: The levels of IgG, IgA and IgM were different at different time points (P<0.05). The levels of IgG, IgA and IgM in the observation group were significantly lower than those in the control group (P<0.05), and the change trend of IgG, IgA and IgM levels in the observation group and the control group was different (P<0.05). The levels of CD3+, CD4+, and CD8+ were different at different time points (P<0.05). The levels of CD3+, CD4+, and CD8+ in the observation group were significantly lower than those in the control group (P<0.05). The change trend of levels of CD3+, CD4+, and CD8+ in the observation group and the control group was different (P<0.05). The levels of IL-2 and IL-4 were different at different time points (P<0.05). The levels of IL-2 and IL-4 in the observation group were significantly lower than those in the control group (P<0.05), and the change trend of IL-2 and IL-4 levels in the observation group and the control group was different (P<0.05). The total incidence of adverse reactions in the observation group was slightly higher than that in the control group (13.33% vs 6.67%, P>0.05). Conclusion: After giving positive blood transfusion to Rh blood group E antigen-negative patients, the patient’s humoral and cellular immune indexes will decrease significantly, which will promote the release of inflammatory factors, without other adverse reactions.
Keywords：
Rh blood group; E antigen; humoral immunity; cellular immunity