血尿酸与急性脑梗死相关危险因素的临床研究
| 作者: |
1刘庆,
2李永光
1 贵州省贵阳市贵航贵阳医院神经内科 2 唐山市协和医院神经内科，河北 唐山 063000 |
| 通讯: |
刘庆
Email: L54410543@sohu.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.01.007 |
摘要
目的：探讨急性脑梗死(acute cerebral infarction，ACI)时血尿酸(serum uric acid，SUA)水平及其与脑梗死相关危险因素的关系。方法：选取2012年1月至6月在唐山市协和医院神经内科住院的ACI病例共50例，检测患者SUA水平，并测定总胆固醇(total cholesterol，TC)、三酰甘油(triglycerides，TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol，LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol，HDL-C)、高敏C反应蛋白(high-sensitivity C-reactive protein，HSC)及纤维蛋白原(fibrinogen，FIB)等。结果：50例ACI患者SUA总体水平为(310.18±100.56) μmol/L，10例为高尿酸血症患者。SUA≥360 μmol/L时ACI伴高尿酸血症患者血HSC升高，与ACI不伴高尿酸血症患者HSC水平比较，差异有统计学意义(P=0.002)，而两者间TG(P=0.907)、TC(P=0.194)、HDL-C(P=0.411)、LDL-C(P=0.396)、FiB(P=0.159)等水平比较，差异无统计学意义。男性ACI患者SUA水平[(348.41±98.78) μmol/L]明显高于女性患者[(280.14±92.93) μmol/L；P=0.016]。50例ACI患者合并高血压者47例，合并2型糖尿病者19例，合并冠心病者36例，与未合并上述疾病患者SUA水平比较差异无统计学意义(均P>0.05)。结论：高尿酸血症在ACI患者中与普通人群中的发生率相当。男性ACI患者高尿酸血症的风险高于女性。高血压、2型糖尿病、冠心病等ACI危险因素对患者SUA水平影响不显著。SUA可能作为一种炎症因子参与并加重ACI的炎症过程，并可能参与多个致病环节，通过多个途径影响疾病的发生、进展及其预后。
关键词：
急性脑梗死；危险因素；血尿酸；高敏C反应蛋白
Acute cerebral infarction risk factors and the level of serum uric acid
CorrespondingAuthor: LIU Qing Email: L54410543@sohu.com
DOI: 10.3978/j.issn.2095-6959.2014.01.007
Abstract
Objective: To investigate the correlation between risk factors of acute cerebral infarction (ACI) and the level of serum uric acid (SUA) and the clinical significance. Methods: A total of 50 patients with ACI were enrolled to measure the levels of SUA, total cholesterol (TG), triglycerides (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), high-sensitivity C-reactive protein (HSC), and fibrinogen (FIB). Results: The average SUA level of all patients after ACI was (310.18±100.56)μmol/L, in which 10 patients were hyperuricemia. The HSC level was elevated when SUA≥360 μmol/L. There was a significant difference in the level of HSC between the ACI patients with and without hyperuricemia (P=0.002), while there were no significant difference in the levels of TG (P=0.907), TC (P=0.194), HDL-C(P=0.411), LDL-C (P=0.396), FIB (P=0.159) between the 2 groups. SUA level in men [(348.41±98.78) μmol/L] was higher than that in women[(280.14±92.93)μmol/L; P=0.016]. Among the 50 ACI patients, 47 complicated with hypertension, 19 with diabetes, and 36 with coronary heart disease. There was no significant difference in SUA levels between ACI patients with and without above-mentioned complications (all P>0.05). Conclusion: Hyperuricemia in patients with ACI displays the similar incidence to general population while the risk in hyperuricemia in men is higher than that in women. Risk factors (such as hypertension, diabetes and coronary heart disease) for ACI show little influence on SUA while SUA might influence ACI through several pathways.