文章摘要

转录因子在上皮间质转化中分子机制研究进展

作者: 1郭鹏, 2董栋栋, 1王进, 1许建发, 1冯和林
1 河北医科大学第四医院 骨科，石家庄 050000
2 河北医科大学第四医院 泌尿外科，石家庄 050000
通讯: 郭鹏 Email: 277051445@163.com
董栋栋 Email: 1837807829@qq.com
王进 Email: wangjin0311@126.com
许建发 Email: 13722988082@163.com
冯和林 Email: fenghelin0311@126.com
DOI: 10.3978/j.issn.2095-6959.2015.03.028
基金: 河北省自然基金面上项目, H2015206314

摘要

上皮细胞-间充质转化(epithelia-mesenchymal transition，EMT)，是指上皮细胞通过特定程序转化为 具有间质表型细胞的生物学过程，目前研究证实这种表型的转化与转录因子密不可分。与其他转 录因子相比，转录因子SNAIL、TWIST、ZEB为促进EMT过程的主要转录因子，本文总结国内外 与EMT相关研究并对转录因子及其在EMT过程中的分子机制加以综述。
关键词： 肿瘤 上皮-间质转化 转录因子 文献综述

Recent progress of research on molecular mechanism of transcription factors in epithelial mesenchymal transition

Authors: 1GUO Peng, 2DONG Dongdong, 1WANG Jing, 1XU Jianfa, 1FENG Helin
1 Department of Orthopedics, the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, China
2 Department of Urinary Surgery, the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, China

CorrespondingAuthor: GUO Peng Email: 277051445@163.com

DOI: 10.3978/j.issn.2095-6959.2015.03.028

Abstract

The transdifferentiation of epithelial cells into motile mesenchymal cells was known as epithelial-mesenchymal transition (EMT). This switch in cell behavior has been illustrated to be mediated and closely related by some key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix–loop–helix transcription factors (TWIST). This article reviewed the research of recent progress of transcription factors the related mechanism of EMT.

文章选项

下载引文

分享