Objective: To explore the application of personalized nursing application effect in patients with cirrhosis. Methods: A total of 180 cases with cirrhosis in our hospital were divided into the research group and the control group, according to the time sequence, 90 cases in each group, routine nursing care was taken in control group patients in the study group with the implementation of personalized nursing. To the patient admission and discharge were All filled out self-rating anxiety scale (SAS), self-rating depression scale (SDS) and Chinese version of health scale (SF-36) and nursing satisfaction questionnaire; record hospitalization time and complications during hospitalization. Results: The SAS and SDS score of the study group (33.73±4.18, 30.19±3.79) were significantly lower than that of the control group (42.12±4.49, 39.75±3.63), with statistically significant difference; SF-36 score of the study group were significantly higher than the control group, the difference has statistical significance; hospitalization time, the number of patients with bad habits and complication rates of the study group were significantly lower than those of the control group, and the patients (95.3%) satisfaction with care was significantly higher than the control group (78.6%), with significant difference. Conclusion: Individual nursing intervention is helpful to reduce SDS and SAS scale of the patients with liver cirrhosis, increase the score of life quality of patients, improve nursing satisfaction, reduce the incidence of complications and the bad habits of patient, short the hospitalization time and so on , has a positive impact on the clinical treatment.