Objective: To evaluate the clinical effects of sevoflurane combined with propofol anesthesia in patients undergoing partial hepatectomy. Methods: A total of 68 patients with partial hepatectomy received in our hospital from May 2018 to May 2020 were taken as the evaluation object. According to the random number table method, the patients were divided into the study group (1.0 MAC sevoflurane combined with Propofol Intravenous Inhalation Combined Anesthesia) and the control group (0.5 MAC sevoflurane combined with Propofol Intravenous Inhalation Combined anesthesia), with 34 patients in each group. The degree of postoperative inflammatory stress and the changes of liver function were analyzed. Results: There was no significant difference in IL-8, IL-10 and TNF-α levels between the 2 groups before operation (P>0.05). After surgery, IL-8 and TNF-α in the study group were lower than those in the control group, while IL-10 was higher than those in the control group, the differences were statistically significant (P<0.05). Cor, NE, E and other indicators in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). After surgery, the ALT level of the study group was (22.08±1.16) U/L, the AST level was (37.08±4.21) U/L, the ALP level was (84.34±3.41) U/L, and the TBil level was (14.16±1.22) μmol/L. All the data were significantly lower than those in control group (all P<0.05). The incidence of complications in the study group was significantly higher than that in the control group (P<0.05). Conclusion: High concentration sevoflurane combined with propofol intravenous inhalation combined anesthesia can effectively regulate inflammatory factors, reduce stress level and improve liver function in patients undergoing partial hepatectomy, but the incidence of complications is relatively high. Clinical treatment should be combined with the actual situation of patients.