Objective: To analyze the effect of compound glycyrrhizin on abnormal liver function during pregnancy and its influence on fetus. Methods: A total of 80 patients with abnormal liver function during pregnancy admitted to our hospital from January 2019 to January 2020 were randomly divided into a control group and an observation group. The observation group was treated with compound glycyrrhizin, and the control group was treated with glutathione. Fasting venous blood was collected before and after the treatment, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) levels were detected by automatic biochemical analyzer. The curative effect, complications, fetal outcome, and satisfaction score were evaluated. Results: There was no significant difference in age, gestational week, and delivery time between the 2 groups (P>0.05). After the treatment, ALT, AST and TBIL levels of the 2 groups were significantly lower than those before the treatment, and ALT, AST and TBIL levels in the observation group were significantly lower than those in the control group (P<0.05). The total effective rate of treatment in the observation group was 92.50%, which was significantly higher than that of the control group (72.50%, P<0.05). There was no significant difference in the incidence of adverse reactions between the 2 groups (P>0.05). The rate of fetal distress and neonatal asphyxia in the observation group were 10.00% and 2.50%, significantly lower than that of the control group (27.50%, 15.00%; both P<0.05). The satisfaction rate of the observation group was 92.50%, which was significantly higher than that of the control group (P<0.05). Conclusion: Compound glycyrrhizin has a good effect on the abnormal liver function of pregnancy. It can improve the liver function effectively with high safety and low influence on fetus, which can be widely used in clinical practice.