文章摘要

内质网应激在急性肺损伤中的研究进展

作者: 1马丽, 2肖敏, 1董良
1 柳州市人民医院麻醉科，广西 柳州 545006
2 柳州市人民医院皮肤科，广西 柳州 545006
通讯: 肖敏 Email: 501880191@qq.com
DOI: 10.3978/j.issn.2095-6959.2022.03.034
基金: 国家自然科学基金 (81760019)；广西壮族自治区卫健委自筹经费科研课题 (Z20210219)。

摘要

内质网是细胞内重要的细胞器之一，主要参与蛋白质的加工和修饰，引导其正确的折叠与组装。在各种刺激因素如感染、氧化应激等的作用下，内质网会发生功能紊乱，导致内质网应激(endoplasmic reticulum stresses，ERS)。持续的ERS可导致未折叠蛋白反应(unfolded protein response，UPR)发生，通过诱导蛋白伴侣分子产生等途径可恢复稳态维持细胞的生存，但持续过度的ERS将导致细胞的死亡。肺内各种细胞内存在大量的内质网，许多肺部相关疾病均与ERS有关。急性肺损伤(acute lung injury，ALI)及急性呼吸窘迫综合征(acute respiratory distress syndrome，ARDS)是临床急重症，其发病机制尚未完全清楚。在不同因素所致ALI动物肺组织中都显示了ERS的存在，表明ERS可能在ALI的发生、发展中起重要作用。
关键词： 急性肺损伤；内质网应激；肺部疾病；未折叠蛋白反应

Research progress of endoplasmic reticulum stress in acute lung injury

Authors: 1MA Li, 2XIAO Min, 1DONG Liang
1 Department of Anesthesiology, Liuzhou Municipal People’s Hospital, Liuzhou Guangxi 545006, China
2 Department of Dermatology, Liuzhou Municipal People’s Hospital, Liuzhou Guangxi 545006, China

CorrespondingAuthor: XIAO Min Email: 501880191@qq.com

DOI: 10.3978/j.issn.2095-6959.2022.03.034

Foundation: This work was supported by the National Natural Science Foundation (81760019) and the Self-funded Scientific Research Project of Health Commission of Guangxi Zhuang Autonomous Region (Z20210219), China.

Abstract

Endoplasmic reticulum is one of the essential organelles in cells, mainly involved in the processing and modifying proteins, guiding its correct folding and assembly. The stimuli, such as infection, oxidative stress, etc., can induce endoplasmic reticulum stress (ERS). Sustained ERS can cause unfolded protein response (UPR), and to restore steady-state maintenance cells by generating protein companion molecules, but continuous excessive ERS will lead to cell death. There are many endoplasmic reticula in various cells in the lung, and many lung-related diseases are related to ERS. Acute lung injury (ALI) and acute respiratory distress syndrome are clinical urgencies, and the pathogenesis has not been fully understood. Endoplasmic reticulum stress was found in the lung tissues of ALI animals caused by different factors, indicating that ERS may play an essential role in the development of ALI.
Keywords： acute lung injury; endoplasmic reticulum stress; lung disease; unfolded protein response

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