血铅、镉、钙、锌及铜水平与孕妇稽留流产的相关性分析
| 作者: |
1朱军,
1梅茹,
1姚超
1 十堰市妇幼保健院妇科，湖北 十堰 442000 |
| 通讯: |
梅茹
Email: 466273280@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.06.036 |
摘要
目的：探讨血铅、镉、钙、锌及铜水平与孕妇稽留流产的相关性。方法：选取2012年6月至2014年
12月我院收治的稽留流产孕妇172例为研究对象(研究组)，同期随机选取200例正常孕妇为对照(对照组)，检测两组患者血铅、镉、钙、锌及铜水平。结果：与对照组比较，研究组孕妇血铅、镉水平较高(P<0.05)，而钙、锌水平较低(P<0.05)，多元回归分析显示：孕妇血铅、镉、钙、锌及铜水平与多种因素相关(职业性铅暴露、镉暴露、被动吸烟、生活饮食习惯、孕期保健等因素)(P<0.05)；多因素Logistic回归分析显示：高血铅、镉、孕妇职业铅暴露、孕妇吸烟、孕期生殖系统感染、近期家庭装潢为孕妇稽留流产危险因素(P<0.05)；而血锌、血钙、补锌、孕期补充维生素为孕妇稽留流产保护性因素(P<0.05)。结论：血铅、镉、钙、锌与孕妇出现稽留流产可能存在一定相关性，值得临床关注。
关键词：
稽留流产
微量元素
重金属
妊娠期
危险因素
12月我院收治的稽留流产孕妇172例为研究对象(研究组)，同期随机选取200例正常孕妇为对照(对照组)，检测两组患者血铅、镉、钙、锌及铜水平。结果：与对照组比较，研究组孕妇血铅、镉水平较高(P<0.05)，而钙、锌水平较低(P<0.05)，多元回归分析显示：孕妇血铅、镉、钙、锌及铜水平与多种因素相关(职业性铅暴露、镉暴露、被动吸烟、生活饮食习惯、孕期保健等因素)(P<0.05)；多因素Logistic回归分析显示：高血铅、镉、孕妇职业铅暴露、孕妇吸烟、孕期生殖系统感染、近期家庭装潢为孕妇稽留流产危险因素(P<0.05)；而血锌、血钙、补锌、孕期补充维生素为孕妇稽留流产保护性因素(P<0.05)。结论：血铅、镉、钙、锌与孕妇出现稽留流产可能存在一定相关性，值得临床关注。
Correlation of blood lead, cadmium, calcium, zinc and copper levels with missed abortion
CorrespondingAuthor: MEI Ru MEI Ru Email: 466273280@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.06.036
Abstract
Objective: To investigate the correlation between blood lead, cadmium, calcium, zinc and copper levels in pregnant women with missed abortion. Methods: A total of 172 cases of pregnant women with missed abortion admitted into our hospital from June 2012 to December 2014 were selected as subjects (research group), meanwhile
200 cases of normal pregnant women were randomly selected as controls (control group); blood lead, cadmium, calcium, zinc and copper were detected in both groups of patients. Results: Compared with the normal group, blood lead and cadmium levels in research group were higher (P<0.05), while the calcium and zinc levels were lower (P<0.05), multiple regression analysis showed that blood lead, cadmium, calcium, zinc and copper levels were related to a variety of factors (occupational exposure to lead, cadmium exposure, passive smoking, diet habits, prenatal care) (P<0.05); Logistic regression analysis showed that high blood lead, cadmium, maternal occupational exposure to lead, maternal smoking during pregnancy, reproductive tract infections, recent residential decoration were the risk factors of missed abortion for pregnant women (P<0.05); while blood zinc, calcium, zinc, vitamin supplements for pregnant women during pregnancy were protective factors of missed abortion (P<0.05). Conclusion: Blood lead, cadmium, calcium, zinc are related to missed abortion of pregnant women. These should be worthy of attention clinically
200 cases of normal pregnant women were randomly selected as controls (control group); blood lead, cadmium, calcium, zinc and copper were detected in both groups of patients. Results: Compared with the normal group, blood lead and cadmium levels in research group were higher (P<0.05), while the calcium and zinc levels were lower (P<0.05), multiple regression analysis showed that blood lead, cadmium, calcium, zinc and copper levels were related to a variety of factors (occupational exposure to lead, cadmium exposure, passive smoking, diet habits, prenatal care) (P<0.05); Logistic regression analysis showed that high blood lead, cadmium, maternal occupational exposure to lead, maternal smoking during pregnancy, reproductive tract infections, recent residential decoration were the risk factors of missed abortion for pregnant women (P<0.05); while blood zinc, calcium, zinc, vitamin supplements for pregnant women during pregnancy were protective factors of missed abortion (P<0.05). Conclusion: Blood lead, cadmium, calcium, zinc are related to missed abortion of pregnant women. These should be worthy of attention clinically