文章摘要

内质网自噬的作用机制

作者: 1郑婉秋, 1李烁, 1吴金峰, 1陈文佳
1 哈尔滨医科大学附属第一医院心内科，哈尔滨 150001
通讯: 陈文佳 Email: chenwenjia0725@163.com
DOI: 10.3978/j.issn.2095-6959.2022.06.030
基金: 国家自然科学基金(81800419)；黑龙江省自然科学基金青年科学基金(QC2017104)。

摘要

内质网自噬(endoplasmic reticulum autophagy，ER-phagy)是指调节内质网的碎片化并将其运送到溶酶体中降解的过程，其作用是降解多余的内质网膜，维持内质网质量和容量的稳态。介导ER-phagy的受体包括FAM134B、RTN3、SEC62、TEX264及CCPG1。当机体发生细胞饥饿、内质网应激(endoplasmic reticulum stress，ER stress)、非折叠蛋白聚集、细菌及病毒的感染等时，ER-phagy就会显著增强。ER-phagy在细胞的生长发育、分化、炎症、免疫防御等过程中发挥重要作用。ER-phagy参与众多疾病的发生与发展，如心血管疾病、肿瘤、神经系统疾病及感染性疾病。深入探索ER-phagy在疾病中的作用机制，研究干预ER-phagy对疾病的影响和预后转归具有重要的临床意义。
关键词： 内质网自噬；内质网应激；自噬受体；心血管疾病；癫痫；肿瘤

Mechanism of endoplasmic reticulum autophagy

Authors: 1ZHENG Wanqiu, 1LI Shuo, 1WU Jinfeng, 1CHEN Wenjia
1 Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor: CHEN Wenjia Email: chenwenjia0725@163.com

DOI: 10.3978/j.issn.2095-6959.2022.06.030

Foundation: This work was supported by the National Natural Science Foundation (81800419) and Young Science Foundation of Natural Science Foundation of Heilongjiang Province (QC2017104), China.

Abstract

Endoplasmic reticulum autophagy (ER-phagy) refers to the process of regulating the fragmentation of the endoplasmic reticulum and transporting it to lysosomes for degradation, which acts to degrade excess ER membranes and maintain the homeostasis of ER mass and capacity. The receptors mediating ER-phagy include FAM134B, RTN3, SEC62, TEX264, and CCPG1. ER-phagy is significantly enhanced when the body undergoes cell starvation, ER stress, unfolded protein aggregation, and bacterial and viral infections. ER-phagy plays an important role in the processes of cell growth and development, differentiation, inflammation, and immune defense. ER-phagy is involved in the occurrence and development of numerous diseases, such as cardiovascular diseases, tumors, neurological diseases, and infectious diseases. It is of great clinical significance to deeply explore the mechanism of ER-phagy in diseases and to study the effects of intervening ER-phagy on diseases and prognostic outcomes.

Keywords： ER-phagy; ER stress; autophagy receptor; cardiovascular disease; epilepsy; tumor

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