锌指蛋白36与癌症
| 作者: |
1丁维珂,
1张小蓉,
1涂剑,
1向蕾
1 南华大学药物药理研究所，湖南 衡阳 421001 |
| 通讯: |
丁维珂
Email: gmam2003@hotmail.com 涂剑 Email: 53840931@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.01.036 |
| 基金: | 国家自然基金, 81100213 湖南省大学生创新性实验计划项目, 2012cshncx5 衡阳市科技局课题, 2013KJ22 博士启动基金, 2011XQD44 湖南省十二五重点学科建设项目 |
摘要
锌指蛋白36(Tristetraprolin, TTP)作为最常见的ARE结合蛋白，通过控制mRNA 3’非翻译区的ARE元件活性来影响mRNA的稳定以及蛋白质的表达。近来研究发现，TTP与多种临床常见癌症如乳腺癌、结肠癌和宫颈癌的增殖、侵袭、转移和预后密切相关。因此作一综述，希望能通过对TTP的研究，有助于对常见癌症的病理诊断以及治疗。
关键词：
锌指蛋白36
癌症
增殖
侵袭
Tristetraprolin and Cancer
CorrespondingAuthor: DING Weike Email: gmam2003@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2015.01.036
Abstract
Tristetraprolin(TTP),a common kind of binding protein with AU-rich elements (AREs),effects on the mRNA stability and the protein expres-sion by regulating the activity of AREs on 3`-untranslated region of mRNA . The recent study has showed that TTP is closely related with the proliferation, invasion, metastasis and prognosis of different kinds of cancer, such as breast cancer, colon cancer, cervical cancer, and so on. Therefore, the review has been written to help the different kinds of cancer on the pathological diagnosis and treatment through a further study of TTP.