Objective: To analyze the clinical effect of the method of Bushen Jianpi Tongluo (invigorating the kidney, strengthening the spleen and clearing the collaterals) in the treatment of Parkinson’s disease (PD) and its effect on inflammatory factors. Methods: Eighty patients with PD admitted to our hospital from January 2018 to December 2020 were selected, and double blind random sampling method was used to divide them into a reference group and an experimental group (40 cases in each group). The reference group adopted routine clinical treatment, and the experimental group adopted the method of Bushen Jianpi Tongluo on the basis of the reference group. The clinical efficacy, Unified Parkinson Rating Scale (UPDRS) score, Pittsburgh Sleep Quality Index (PSQI) score, PDNMS30 Questionnaire Scale (NMSQuest) score, and serum inflammatory factors were compared between the two groups. Results: The total clinical effective rate of the experimental group (95.00%) was significantly higher than that of the reference group (62.50%). The UPDRS score, PSQI score, NMSQuest score, serum IL-1β, IL-6, TNF-α, and IFN-γ factors in the experimental group were significantly lower than those in the reference group after 4 weeks of treatment (P<0.05). The incidence of adverse reactions between the reference group and the experimental group was 17.07% and 14.63%, and there was no statistically significant difference between the groups (P>0.05). Conclusion: The method of invigorating the kidney, strengthening the spleen and dredging collaterals can effectively improve the condition of PD patients and inhibit the release of inflammatory mediators. The clinical effect is significant and it is worth learning.