非小细胞肺癌患者外周血循环肿瘤细胞与临床特征关系的 初步研究
| 作者: |
1,2万佳蔚,
2沈洪远,
2黄红宇,
2韩志君,
2严子禾,
2高明珠,
1黄新祥
1 江苏大学基础医学与医学技术学院，江苏 镇江 212013 2 无锡市第二人民医院检验科，江苏 无锡 214002 |
| 通讯: | |
| DOI: | 10.3978/j.issn.2095-6959.2015.01.013 |
| 基金: | 无锡市医院管理中心医学科技项目, YGZXQ1310 |
摘要
目的：评价非小细胞肺癌(non-small cell lung cancer，NSCLC)患者的外周静脉血循环肿瘤细胞 (circulating tumor cells，CTC)计数的临床应用价值。方法：收集2013年1月～2013年12月无锡市 第二人民医院诊断的50例NSCLC作为研究对象，同时收集良性肺部疾病患者35例及28例体检健康 者。采集上述各研究组静脉血标本，检测静脉血CTC的数量，≥8.7单位判定为阳性。分析CTC计 数与患者年龄、性别、病理类型及临床分期之间的关系。结果：NSCLC患者CTC计数显著高于良 性肺部疾病对照组和健康对照组。NSCLC患者外周血中CTC与患者性别、年龄、病理类型无明显 关系(P>0.05)，CTC数值随着肿瘤临床分期递进而增加(P<0.01)。结论：NSCLC的CTC计数与患者 临床特征具有一定相关性，可初步反映患者的疾病状态。
关键词：
循环肿瘤细胞
非小细胞肺癌
临床特征
A preliminary study on the relationship between circulating tumor cells count and clinical features in patients with non-small cell lung cancer
DOI: 10.3978/j.issn.2095-6959.2015.01.013
Abstract
Objective: To evaluate the clinical value of circulating tumor cells (CTC) count in peripheral venous blood of patients with non-small cell lung carcinoma (NSCLC). Methods: Totally 50 patients with NSCLC in Wuxi No. 2 people’s Hospital were selected for study from January 2013 to December 2013, 35 patients with lung benign tumor and 28 normal volunteers were selected as the control groups. CTC collected from 3 mL venous blood of all people above were counted. Patients with 8.7 units or more CTC were judged to be positive. The relationship between the positive rate of CTC and the age, sex, pathological type and clinical stage was analyzed. Results: CTC count was significantly higher in NSCLC patients than in benign lung patients and healthy controls. CTC count in NSCLC patients was rarely related to the sex, age or the pathological type (P>0.05) and was closely related to clinical stage (P<0.01). Among NSCLC patients, CTC count significantly increased along with tumor progression. Conclusion: The progression of patients with non-small-cell lung carcinoma was associated with the level of CTC count which can reflect the status of the patients to some extent.