Objective: To investigate the predictive value of waist circumference in early incision-related complications after kidney transplantation. Methods: From January 2020 to March 2021, 127 patients underwent kidney transplantation in our hospital were selected, including 24 patients with incision-related complications in the early postoperative period (an incision-related complications group) and 103 patients without incision-related complications in the early postoperative period (a no incision-related complications group). Differences in gender, age, smoking history, diabetes, waist circumference, body mass index (BMI), type of organ donation, operation time, abdominal closure, fascial closure suture, low serum albumin after operation, and anti-human leukocyte antigen (HLA) antibody were compared between the two groups. Multivariate Logistic regression was used to analyze the predictors of incision-related complications in the early stage after renal transplantation, and the subject operating characteristic (ROC) curve was used to evaluate the predictive value of related variables for incision-related complications. Results: The proportion of patients in the incision complication group with longer waist circumference (male ≥85 cm, female ≥80 cm), higher BMI (≥28 kg/m2) and longer operation time (≥4 h) was significantly higher than that in the non-incision complication group, and the proportion of patients with low serum albumin after operation and anti HLA antibody positive was significantly higher than that in the non-incision complication group (P<0.05). There was no significant difference between the two groups in gender, age, smoking history, diabetes mellitus, organ donation type, abdominal closure and fascial suture closure (P>0.05). Multivariate logistic regression analysis found that waist circumference (≥85 cm for men and ≥80 cm for women), low serum albumin after operation and anti-HLA antibody positive were independent predictors of incisional complications in the early stages of renal transplantation (P<0.05). ROC curve analysis showed that waist circumference (≥85 cm for men and ≥80 cm for women) had a sensitivity of 83.3% and specificity of 88.3%, and the area under the curve (AUC) was 0.858 (95%CI: 0.765–0.952) for predicting incisions related complications after renal transplantation. Conclusion: Waist circumference has predictive value in early incision-related complications after renal transplantation, and preoperative waist circumference measurement can help accurately screen out high-risk patients and make doctors take intervention measures as soon as possible.