Objective: To investigate the effect of endoscopic submucosal turbinectomy combined with nasal septum correction on olfactory sensation in patients with allergic rhinitis (AR) with deviation of nasal septum. Methods: A total of 150 AR patients with nasal septum deviation from June 2017 to December 2020 were randomly divided into an observation group (n=75) and a control group (n=75). Nasal septum correction was performed in both groups, and the observation group was combined with submucosal partial turbinate resection under nasal endoscope. The nasal symptoms, airway responsiveness, and olfactory function of the 2 groups were evaluated before and 1 month after the operation, and the postoperative quality of life [Rhinitis related Quality of Life Questionnaire (RQLQ)] and the incidence of complications were compared between the 2 groups. Results: One month after the operation, the scores of nasal itching, sneezing, nasal congestion, snot, respiratory resistance at 5 Hz (R5), respiratory resistance at 20 Hz (R20), resonance frequency (Fres) and olfactory recognition threshold in the observation group were lower than those in the control group (P<0.05). One month after operation, the rate of good sense of smell in both groups was higher than that before the operation, and the rate of good sense of smell in the observation group was higher than that in the control group (P<0.05). The scores of nasal symptoms, eye symptoms, other symptoms, behavioral problems, and sleep disorders in the observation group were lower than those in the control group (all P<0.05), but there was no significant difference in the incidence of complications between the 2 groups (P>0.05). Conclusion: Endoscopic submucosal turbinectomy combined with nasal septum correction is a good method for the treatment of AR with nasal septum deviation, which is helpful to promote the recovery of olfactory function after operation.