With the development of biotechnology and deep research of the structure and function of antibodies, the progress of anti-tumor antibody drugs can be summarized three stages: naked antibody, monoclonal antibody and its derivatives, and gene engineering antibody. This article ummarizes the progress and current situation of the anti-tumor antibody drugs, the types and characteristics of these drugs, and the basic principle of antibody drug treatment for tumor. In addition, the trends from a single target to multiple antibody targets, the efficiency and miniaturization of antibody drugs and the boom of antibodomic and antibodomic medicine are also discussed.