文章摘要

长链非编码 RNA OIP5-AS1 在肿瘤中的研究进展

作者: 1李晓丹, 2,3方学红, 2,3蒋代顺, 1林杰, 3,4刘义, 1邹丽宜
1 广东医科大学(东莞校区)药学院，广东 东莞 523808
2 广东医科大学(湛江校区)药学院，广东 湛江 524023
3 广东医科大学广东天然药物研究与开发实验室，广东 湛江 524023
4 广东医科大学海洋医药研究院，广东 湛江 524023
通讯: 刘义 Email: plliu78@sina.com
邹丽宜 Email: 442516867@qq.com
DOI: 10.3978/j.issn.2095-6959.2022.04.030
基金: 国家自然科学基金(82073054)。

摘要

长链非编码RNA(long non-coding RNA，lncRNA)与肿瘤的发生发展密切相关。LncRNA反义Opa反 应蛋白5RNA(Opa interacting protein 5-antisense RNA 1，OIP5-AS1)在多种肿瘤中不仅异常表达，还 发挥癌基因的作用，是潜在的肿瘤治疗靶点，并有望成为肿瘤诊断和预后新的标志物。本文就近 年来OIP5-AS1在肿瘤中作用的相关研究作一综述，以期为OIP5-AS1的临床应用提供依据。
关键词： 长链非编码RNA；反义Opa反应蛋白5RNA；肿瘤

Research progress of long non-coding RNA OIP5-AS1 in cancer

Authors: 1LI Xiaodan, 2,3FANG Xuehong, 2,3JIANG Daishun, 1LIN Jie, 3,4LIU Yi, 1ZOU Liyi
1 School of Pharmacy, Guangdong Medical University (Dongguan Campus), Dongguan Guangdong 523808, China
2 School of Pharmacy, Guangdong Medical University (Zhanjiang Campus), Zhanjiang Guangdong 524023, China
3 Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang Guangdong 524023, China
4 Marine Medicine Research Institute, Guangdong Medical University, Zhanjiang Guangdong 524023, China

CorrespondingAuthor: LIU Yi Email: plliu78@sina.com

DOI: 10.3978/j.issn.2095-6959.2022.04.030

Foundation: This work was supported by the National Natural Science Foundation of China (82073054).

Abstract

Long non-coding RNA (lncRNA) is closely associated with the occurrence and development of tumors. LncRNA Opa interacting protein 5-antisense RNA 1 (OIP5-AS1) is not only abnormally expressed in a variety of tumors, but also acts as an oncogene. It is a potential tumor for treatment target which is expected to become a new marker for tumor diagnosis and prognosis. In this essay, we will provide a brief overview of the recent relevant studies on the function of OIP5-AS1 in tumors with a view to providing evidence for its clinical use.
Keywords： long non-coding RNA; Opa interacting protein 5-antisense RNA; tumors

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