Objective: To explore the effect of self-made Honghuang decoction combined with Baduanjin in the chemotherapy of elderly patients with breast tumors. Methods: A prospective, double-blind, controlled study was conducted, and 108 elderly patients with breast cancer treated with chemotherapy in our hospital from October 2018 to December 2019 were selected and randomly divided into two groups, 54 cases in each group. The control group was given self-made Honghuang decoction for intervention while the observation group was combined with Baduanjin intervention on this basis. In addition, 54 patients with chemotherapy alone were selected as the chemotherapy group, and the changes of serum NO, SOD content, negative emotion, fatigue degree and quality of life were compared among the 3 groups before and after intervention. Results: The NO content and SOD content of the 3 groups were compared on the 7th and 14th day of chemotherapy, and the difference was not statistically significant (P>0.05). The SAS and SDS scores of the observation group were lower than those of the control group and the chemotherapy group 4 months after the intervention (P<0.05). The observation group’s general fatigue, current fatigue, most fatigue, and total scores were lower than those of the control group and chemotherapy group 4 months after the intervention (P<0.05). The physical, emotional, social/family, additional attention, function, and total scores of the observation group were higher than those of the control group and the chemotherapy group 4 months after the intervention (P<0.05). Conclusion: The self-made Honghuang decoction combined with Baduanjin has a significant effect on the chemotherapy of elderly patients with breast tumors. It can relieve patients’ negative emotions and fatigue, and improve the quality of life. It is worth promoting.