中国人饮食因素与食管癌的相关性
作者: |
1宋文鹏,
1王彦,
2谢嘉渝,
3赖玉田,
1李佳龙,
1胡杨
1 四川大学华西医院胸外科,成都 610041 2 成都市双流区疾病预防控制中心,成都 610200 3 四川大学华西医院肺癌中心,成都 610041 |
通讯: |
胡杨
Email: huyangthoracic@126.com |
DOI: | 10.3978/j.issn.2095-6959.2021.08.031 |
基金: | 四川省科技计划项目(重点研发项目)(2017SZ0189)。 |
摘要
目的:探究中国人群饮食因素与食管癌发病的相关性。方法:通过计算机检索中国知网、维普、万方等数据库中公开发表的文献,检索时间为2011—2021年,收集饮食因素与食管癌关系的文献,荟萃分析使用Stata 12.0软件完成,合并比值比(odds ratio,OR)及其95%置信区间(confidence interval,CI)。结果:共纳入28项回顾性研究,合计病例组患者6 668例,对照组患者9 468例。吸烟、喜食腌制食物、食霉变食物、暴饮暴食、饮用生水、吃熏烤食物、喜食油炸、喜食辣食、吃咸食、不按时进食、喜食干硬食物、饮酒、进食过快、吃烫食合并OR值及其95%CI均>1。三餐按时、吃肉蛋禽奶、喜食蔬菜、喜食水果合并OR值及其95%CI均<1。合并饮茶的OR值无统计学意义。敏感度分析和发表偏倚检测的结果表明本研究受发表偏倚影响较小,结果较为稳定、可靠。结论:吸烟、喜食腌制食物、食霉变食物、暴饮暴食、饮用生水、吃熏烤食物、喜食油炸、喜食辣食、吃咸食、不按时进食、喜食干硬食物、饮酒、进食过快、吃烫食可能是食管癌的危险因素。三餐按时、吃肉蛋禽奶、喜食蔬菜、喜食水果可能是食管癌的保护因素,饮茶与食管癌的关系尚不能明确。
关键词:
食管癌;饮食;因素;荟萃分析
Association between dietary factors and esophageal cancer in Chinese population
CorrespondingAuthor: HU Yang Email: huyangthoracic@126.com
DOI: 10.3978/j.issn.2095-6959.2021.08.031
Foundation: This work was supported by the Science and Technology Planning Project of Sichuan Province (Key R & D Project), China (2017SZ0189).
Abstract
Objective: To explore the relationship between dietary factors and the incidence of esophageal cancer in the Chinese population. Methods: Published literature in databases such as CNKI, VIP, Wanfang, and other databases were searched for eligible studies from 2011 to 2021. The literature on the relationship between dietary factors and esophageal cancer was collected. We combined both odds ratios (OR) and 95% confidence interval (CI) by using Stata 12.0 software. Results: A total of 28 retrospective studies were included, with a total of 6 668 patients in the case group and 9 468 patients in the control group. The meta-analysis results showed that the OR values (95% CI) of cigarette smoking, pickled food, moldy or spoiled food, overeating, drinking unboiled water, smoked and roasted food, fried food, spicy food, salty food, irregular diet, dry and hard food, alcohol drinking, quick eating, eating hot food were all greater than 1. The OR values (95% CI) of having meals on time, frequently eating meat, eggs and milk, vegetables, and fruits were all less than 1. The OR values (95% CI) of tea drinking were not statistically significant. The sensitivity analysis and publication bias detection results indicated that our findings were of robustness and less affected by publication bias. Conclusion: The risk factors of esophageal cancer include cigarette smoking, pickled food, moldy or spoiled food, overeating, drinking unboiled water, smoked and roasted food, fried food, spicy food, salty food, irregular diet, dry and hard food, alcohol drinking, quick eating, eating hot food, while the protective factors of esophageal cancer include having meals on time, frequently eating meat, eggs and milk, vegetables, and fruits. The relationship between tea drinking and esophageal cancer is still unclear.
Keywords:
esophageal cancer; dietary habits; factors; meta-analysis