Objective: To explore the clinicopathological characteristics and immuophenotypes of pulmonary sclerosing pneumocytoma (PSP). Methods: The clinicopathological data of 36 PSP patients meeting the enrollment requirements were collected. The clinical manifestations, imaging and pathological characteristics, and immunophenotypes of the disease were analyzed. Results: PSP was most commonly seen in middle-aged females. Patients were typically asymptomatic. Imaging examination revealed that PSP presented with a solitary well-circumscribed mass. The key pathological features included circumscribed lesion, two types of tumor cells and four typical histological patterns. By immunohistochemistry, two types of tumor cells expressed TTF1, EMA and p-AKT. Additionally, cuboidal cells expressed CK, whereas round cells were positive for vimentin and usually positive for ER, PR. Neither of them expressed BRAF V600E. All the patients had no recurrence and metastasis during the follow-up. Conclusion: PSP lacks special clinical and imaging manifestations, but having diverse histological patterns. The pathological diagnosis depends on the key morphologic features including two types of tumor cells and four patterns and immunohistochemical staining. PSP clinically behaves in a benign fashion.