育龄期女性生殖道感染解脲支原体、沙眼衣原体情况及其与输卵管不孕间的相关性
| 作者: |
1罗秀梅,
2李晓芳,
3王荣
1 新疆维吾尔自治区生殖健康医院检验科，乌鲁木齐 830000 2 新疆维吾尔自治区和田地区于田县妇幼保健站妇保科，新疆 和田 848400 3 新疆维吾尔自治区生殖健康医院妇科，乌鲁木齐 830000 |
| 通讯: |
罗秀梅
Email: hjhttyh@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.10.011 |
摘要
目的：观察育龄期女性生殖道感染解脲支原体、沙眼衣原体感染情况及其与输卵管不孕间的相关性。方法：选取2018年1月到2020年11月在新疆维吾尔自治区生殖健康医院就诊的100例育龄期患输卵管不孕患者为观察组，同期选取100例育龄期女性体检非输卵管不孕者为对照组，比较两组白细胞介素-2(interleukin 2，IL-2)、肿瘤坏死因子-α(tumor necrosis factor -α，TNF-α)水平；两组阴道分泌物解脲支原体(ureaplasma urealyticum，UU)、沙眼衣原体(chlamydia trachomatis，CT)检出率；行Spearman相关性分析得出IL-2、TNF-α水平与输卵管不孕的关联度以及生殖道UU、CT感染与IL-2、TNF-α水平的关联度；分析UU、CT药敏性结果。结果：观察组体检当天血清IL-2、TNF-α水平显著高于对照组(P<0.05)；观察组UU、CT感染率显著高于对照组(P<0.05)；IL-2、TNF-α水平与输卵管不孕发生呈正相关(P<0.05)；生殖道UU、CT感染与IL-2、TNF-α水平呈正相关(P<0.05)；UU、CT对氧氟沙星的耐药率最高，分别为38.54%、41.67%；对多西霉素耐药率最低，分别为1.04%、0.00%；结论：输卵管不孕发生和UU、CT感染与炎症反关系紧密，输卵管不孕患者发生UU、CT感染阳性率较高，提示生殖道UU、CT感染可能与输卵管不孕有关，临床应重视对输卵管不孕妇女对UU、CT感染的检查和用药选择。
关键词：
育龄期女性；解脲支原体；沙眼衣原体；输卵管不孕；相关性
Infection of ureaplasma urealyticum and chlamydia trachomatis in reproductive tract in women of childbearing age and tubal infertility
CorrespondingAuthor: LUO Xiumei Email: hjhttyh@163.com
DOI: 10.3978/j.issn.2095-6959.2021.10.011
Abstract
Objective: To study the infection of ureaplasma urealyticum (UU) and chlamydia trachomatis (CT) in reproductive tract in women of childbearing age and its correlation with tubal infertility. Methods: A total of 100 patients with tubal infertility in childbearing age admitted to Xinjiang Uygur Autonomous Region Reproductive Health Hospital from January 2018 to November 2020 were selected as the observation group, and 100 women of childbearing age with non-tubal infertility were selected as the control group. The levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) were compared between the two groups. The detection rates of UU and CT in vaginal secretions were compared between the two groups. Spearman correlation analysis was performed to obtain the correlation between IL-2 and TNF-α levels and tubal infertility, and the correlation between UU and CT infection of reproductive tract and IL-2 and TNF levels. The results of sensitivity of UU and CT to drug were analyzed. Results: The levels of serum IL-2 and TNF-α in the observation group on the day of physical examination were significantly higher than those in the control group (P<0.05). The infection rate of UU and CT in the observation group was significantly higher than that in the control group (P<0.05). The levels of IL-2 and TNF-α were positively correlated with tubal infertility (P<0.05). UU and CT infection of reproductive tract were positively correlated with IL-2 and TNF-α levels (P<0.05). The drug resistance rates of UU and CT to ofloxacin were the highest, which were 38.54% and 41.67%, respectively. Their resistance rate to doxymycin was the lowest, which was 1.04% and 0.00%, respectively. Conclusion: The occurrence of tubal infertility is closely related to UU and CT infection and inflammation. The positive rate of UU and CT infection in patients with tubal infertility is higher, suggesting that reproductive tract UU and CT infection may be related to tubal infertility. Clinically, attention should be paid to the examination of UU and CT infection in women with tubal infertility and the choice of medication.
Keywords：
women of childbearing age; ureaplasma urealyticum; chlamydia trachomatis; tubal infertility; correlation