Objective: To understand the clinical status and analyze the influencing factors of return-to-work readiness of breast cancer patients after operation. Methods: From June 2018 to December 2019, 271 breast cancer patients who have been treated in the First Affiliated Hospital of Zhengzhou University for operation were conveniently selected, and were investigated with the return-to-work readiness scale, medical social support scale, and self-efficacy scale. Results: The score of the return-to-work readiness of postoperative breast cancer patients was 2.76±0.85, social support score was 70.43±6.04, and self-efficacy score was 41.45±4.93; age, monthly income, actual support, information and emotional support, social interaction and cooperation, psychological support, and self-efficacy were all independent influencing factors for return-to-work readiness, which can explain 64.2% of variance (all P<0.05). Conclusion: The preparation for returning to work in breast cancer patients is relatively insufficient. Clinical staff can set targeted measures according to the patient’s situation, pay attention to strengthening social support and enhance the individual’s sense of self-efficacy, to help the patients to be adaptable to their jobs and the society.