文章摘要

长链非编码RNA在结直肠癌诊断及预后中的研究进展

作者: 1,2霍超, 1,2方学红, 1,2蒋代顺, 1刘义
1 广东医科大学广东天然药物研究与开发重点实验室，广东 湛江 524023
2 广东医科大学药学院，广东 湛江 524023
通讯: 刘义 Email: plliu78@sina.com
DOI: 10.3978/j.issn.2095-6959.2022.01.030
基金: 广东省自然科学基金(2018A0303130252)。

摘要

早期诊断和预后标志物的缺乏是导致结直肠癌(colorectal cancer，CRC)患者生存率低的主要原因。长链非编码RNA(long non-coding RNA，lncRNA)由于在CRC发生发展中发挥重要的作用，并且能在外周血中稳定存在，而被认为是具有潜在临床应用价值的生物标志物。
关键词： 结直肠癌；长链非编码RNA；早期诊断；预后；生物标志物

Research progress of long non-coding RNA in the diagnosis and prognosis of colorectal cancer

Authors: 1,2HUO Chao, 1,2FANG Xuehong, 1,2JIANG Daishun, 1LIU Yi
1 Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang Guangdong 524023, China
2 School of Pharmacy, Guangdong Medical University, Zhanjiang Guangdong 524023, China

CorrespondingAuthor: LIU Yi Email: plliu78@sina.com

DOI: 10.3978/j.issn.2095-6959.2022.01.030

Foundation: This work was supported by the Natural Science Foundation of Guangdong Province, China (2018A0303130252).

Abstract

Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The lack of early diagnosis and prognostic markers are the main reasons for the low survival rate of CRC patients. Long non-coding RNA (lncRNA) is considered a biomarker with potential clinical application due to its important role in the occurrence and development of CRC and its stable presence in peripheral blood.
Keywords： colorectal cancer; long non-coding RNA; early diagnosis; prognosis; biomarkers

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