Objective: To study the effects of continuous femoral nerve block (CFNB) combined with parecoxib on postoperative stress response and pain degree in elderly patients who underwent hip fracture surgery. Methods: A total of 80 elderly patients undergoing hip fracture surgery who were admitted to the hospital from January 2018 to December 2020 were enrolled and randomly divided into a parecoxib group (parecoxib) and a CFNB group (CFNB combined with parecoxib) according to different treatment methods, with 40 cases in each group. The operation time, hospitalization time, and intraoperative blood loss, scores of Visual Analogue Scale (VAS) and levels of stress factors [malondialdehyde (MDA), cortisol (Cor), aldosterone (ALD)] at different time points [before surgery (T₁), after surgery (T₂), 24 h after surgery (T₃)] were compared between the two groups. The sufentanil dosage and occurrence of complications in both groups at different time points [T₃, 48 h after surgery (T₄), 72 h after surgery (T₅)] were recorded. Results: The hospitalization time in study group was shorter than that in the control group (P<0.05). The VAS scores of static and exercise status in the CFNB group were lower than that in the parecoxib group at different time points (P<0.05). The levels of MDA, Cor and ALD were increased in both groups, whose increase were more significant in parecoxib group than the CFNB group (P<0.05). The sufentanil dosage in CFNB group was less than that in parecoxib group at different time points (P<0.05). The incidence of complications in CFNB group was lower than that in parecoxib group (17.50% vs 40.00%) (P<0.05).
Conclusion: The application of CFNB combined with parecoxib in the elderly after hip fracture surgery can effectively relieve pain, shorten hospitalization time, reduce stress response and dosages of analgesics, with high safety.